DNA Nanomachine Switching Improved by Cationic Comb-Type Copolymer
DNA Nanomachine Switching Improved by Cationic Comb-Type Copolymer
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DOI：
10.1002/masy.200750352
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发表时间：
2007-04
影响因子：
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通讯作者：
S. Choi;Naoki Makita;Arihiro Kano;A. Yamayoshi;T. Akaike;A. Maruyama
中科院分区：
文献类型：
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作者：
S. Choi;Naoki Makita;Arihiro Kano;A. Yamayoshi;T. Akaike;A. Maruyama
DNA独特的折叠和组装特性已被详细阐述，以构建各种纳米机器，这些机器可以在两个或更多不同的构象之间进行可逆切换。为了更好地应用和发展DNA纳米机器，需要改进它们的响应动力学、产量和序列选择性。此外，目前的DNA纳米机器在操作条件上存在一些限制，如温度、盐条件和DNA链浓度。在这项研究中，我们评估了阳离子共聚物对DNA燃料纳米机器响应的影响。我们发现，即使在非常低的链浓度(NM范围)下，共聚物也能在适度的条件下提高纳米机器的速度，包括生理相关的条件。
The unique folding and assembling properties of DNA have been elaborated to construct various nanomachines that can be reversibly switched between two or more distinct conformations. For the better applications and developments of DNA nanomachines, their responding kinetics, outputs, and sequence-selectivity need to be improved. Furthermore, the DNA nanomachines currently have several limitations in the operation conditions such as temperature, salt condition, and DNA strand concentration. In this study, we evaluated the effect of a cationic copolymer on the responses of a DNA-fueled nanomachine. We found that the copolymer increases quickness of the nanomachine under moderate conditions including physiologically relevant conditions even at very low strand concentrations (nM range).