Preliminary study on sex-related inflammatory reactions in mice infected with Schistosoma mansoni
Preliminary study on sex-related inflammatory reactions in mice infected with Schistosoma mansoni
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DOI：
10.1007/s00436-003-0943-1
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发表时间：
2003-09-01
影响因子：
2
通讯作者：
Moné, H
中科院分区：
文献类型：
--
作者：
Boissier, J;Chlichlia, K;Moné, H
本研究的目的是探讨寄生虫和宿主的性别对小鼠单性感染曼氏血吸虫引起的炎症反应的贡献。在这项比较研究中，使用器官重量、细胞计数和迟发型超敏反应作为工具。作为宿主和寄生虫的性别的函数，炎症反应不同。雌性小鼠对染色体感染的炎症反应比雄性小鼠更强，而雄性染色体诱导的炎症反应比雌性小鼠更强。炎症反应中与宿主相关的差异可能反映了影响雄性和雌性小鼠免疫防御的因素的差异。寄生虫引起的炎症反应的差异进行了讨论的数量和质量的抗原之间的男性和女性蠕虫。
The aim of this study was to investigate the contribution of the sex of both the parasite and the host to the inflammatory response induced in unisexual infections of Schistosoma mansoni in mice. Organ weight, cell count and the delayed type hypersensitivity reaction were used as tools in this comparative study. The inflammatory reactions differed as a function of the sex of both the host and the parasite. Female mice showed a stronger inflammatory reaction to schistosome infection than males, while male schistosomes induced a stronger inflammatory response compared to females. The host-related differences in the inflammatory reaction may reflect differences in the factors affecting the immune defence of male and female mice. The differences in the inflammatory response induced by the parasite are discussed in terms of the quantity and quality of antigens among male and female worms.