Enzymatic synthesis of sugar fatty acid esters in ionic liquids
Enzymatic synthesis of sugar fatty acid esters in ionic liquids
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DOI：
10.1039/c2cy20109g
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发表时间：
2012-08
影响因子：
5
通讯作者：
Zhen Yang;Ze-Lin Huang
中科院分区：
文献类型：
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作者：
Zhen Yang;Ze-Lin Huang
糖脂肪酸酯是非离子生物表面活性剂，广泛应用于食品、化妆品和制药行业。离子液体（IL）作为传统有机溶剂的酶促合成替代反应介质显示出巨大的潜力，可显着提高糖溶解度、酶反应活性和区域选择性。从这个角度出发，我们总结了使用离子液体作为糖溶解溶剂和脂肪酶催化糖酯合成的进展，回顾了设计与酶相容的离子液体用于合成的最新成果，并讨论了该课题的研究面临的挑战。在先进的离子液体中，低共熔溶剂 (DES) 作为该应用的潜在反应介质值得认真考虑。
Sugar fatty acid esters are nonionic biosurfactants widely used in food, cosmetic and pharmaceutical industries. Ionic liquids (ILs) have shown great potential as an alternative reaction medium to conventional organic solvents for their enzymatic synthesis, promoting a significant enhancement in sugar solubility, enzymatic reactivity and regioselectivity. In this perspective, we summarize the advances in the use of ILs as a solvent for sugar dissolution and lipase-catalyzed sugar ester synthesis, review the recent achievements in designing enzyme-compatible ILs for the synthesis, and discuss the challenges that the research on this topic is facing. Among the advanced ILs, deep eutectic solvents (DESs) merit a serious consideration as a potential reaction medium for this application.