Cytosolic and nuclear recognition of virus and viral evasion.
Cytosolic and nuclear recognition of virus and viral evasion.
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病毒的胞质和核识别以及病毒逃避
DOI：
10.1186/s43556-021-00046-z
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发表时间：
2021-10-10
影响因子：
4
通讯作者：
You F
中科院分区：
文献类型：
--
作者：
Li S;Cao L;Zhang Z;Kuang M;Chen L;Zhao Y;Luo Y;Yin Z;You F
先天免疫系统是宿主防御的第一道防线，对病毒感染反应迅速。病毒的先天识别是由一组模式识别受体（PRRs）介导的，这些受体感知病毒基因组核酸和/或复制中间体。PRRs主要定位于核内体、质膜或细胞质。最近的证据表明，位于细胞核中的几种蛋白质也可以作为病毒传感器。反过来，这些重要元素正成为大多数病毒逃避宿主免疫监视的目标。本文就病毒识别和逃避的研究进展作一综述。
The innate immune system is the first line of host defense, which responds rapidly to viral infection. Innate recognition of viruses is mediated by a set of pattern recognition receptors (PRRs) that sense viral genomic nucleic acids and/or replication intermediates. PRRs are mainly localized either to the endosomes, the plasma membrane or the cytoplasm. Recent evidence suggested that several proteins located in the nucleus could also act as viral sensors. In turn, these important elements are becoming the target for most viruses to evade host immune surveillance. In this review, we focus on the recent progress in the study of viral recognition and evasion.