Transdermal iontophoresis of sodium nonivamide acetate - V. Combined effect of physical enhancement methods
Transdermal iontophoresis of sodium nonivamide acetate - V. Combined effect of physical enhancement methods
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DOI：
10.1016/s0378-5173(01)00972-3
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发表时间：
2002-03-20
影响因子：
5.8
通讯作者：
Tsai, YH
中科院分区：
文献类型：
--
作者：
Fang, JY;Hwang, TL;Tsai, YH
本文研究了离子导入结合电穿孔、低频超声和铒：YAG（钇铝石榴石）激光等物理促进方法对醋酸诺尼伐胺钠（SNA）透皮吸收的影响。与被动扩散相比，离子导入增加了SNA的体外透皮通量。此外，在所测试的物理增强方法中，离子电渗疗法始终是SNA渗透的最有效的增强方法。脉冲的高电压（电穿孔），然后通过离子电渗没有导致增加的运输比单独的离子电渗。然而，电穿孔缩短了SNA的经皮离子电渗递送的开始。低频超声波（超声促渗）单独对皮肤的预处理并不增加SNA的皮肤渗透。离子电渗和超声促渗的组合增加了SNA的经皮转运比每种方法本身。在电场存在下，药物跨分流途径转运的增强和阈值电压的降低可能有助于这种协同效应。使用铒：YAG激光是一种很好的方法，用于增强SNA的透皮吸收，因为它可以精确控制角质层（SC）的去除，并且这种SC的消融可以逆转到原始的正常状态。激光治疗和离子电渗疗法的组合也协同SNA的皮肤渗透，这可能是由于皮肤电阻的逐渐下降。本研究的结果指出，选择一定的条件与适当的物理增强方法可以诱导协同效应SNA的经皮给药在离子导入。(C)2002 Elsevier Science B.V.保留所有权利。
The effect of iontophoresis combined with treatment of other physical enhancement methods such as electroporation, low frequency ultrasound, and erbium:YAG (yttrium- aluminum- garnet) laser on the transdermal delivery of sodium nonivamide acetate (SNA) was examined in this present study. Iontophoresis increased the transdermal flux of SNA in vitro as compared to the passive diffusion without any enhancement. Furthermore, iontophoresis was always the most potent enhancement method for SNA permeation among the physical enhancement methods tested. Pulsing of high voltages (electroporation) followed by iontophoresis did not result in increased transport over iontophoresis alone. However, electroporation shortened the onset of transdermal iontophoretic delivery of SNA. Pretreatment of low frequency ultrasound (sonophoresis) alone on skin did not increase the skin permeation of SNA. The combination of iontophoresis and sonophoresis increased transdermal SNA transport more than each method by itself. The enhancement of drug transport across shunt routes and reduction of the threshold voltage in the presence of an electric field may contribute to this synergistic effect. Use of an erbium:YAG laser was a good method for enhancing transdermal absorption of SNA because it allows precise control of stratum corneum (SC) removal, and this ablation of SC could be reversible to the original normal status. The combination of laser treatment and iontophoresis also synergized the skin permeation of SNA, possibly due to a gradual drop in the electric resistance of the skin. The results in this present study point out that the choice of certain conditions with suitable physical enhancement methods can induce a synergistic effect on transdermal delivery of SNA during iontophoresis. (C) 2002 Elsevier Science B.V. All rights reserved.