Relation of Sex Hormone Levels With Prevalent and 10-Year Change in Aortic Distensibility Assessed by MRI: The Multi-Ethnic Study of Atherosclerosis.
Relation of Sex Hormone Levels With Prevalent and 10-Year Change in Aortic Distensibility Assessed by MRI: The Multi-Ethnic Study of Atherosclerosis.
复制标题
性激素水平与 MRI 评估的主动脉扩张性普遍变化和 10 年变化的关系：动脉粥样硬化的多种族研究。
DOI：
10.1093/ajh/hpy024
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发表时间：
2018
影响因子：
3.2
通讯作者：
Michos,E
中科院分区：
文献类型：
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作者：
Subramanya,Vinita;Ambale-Venkatesh,Bharath;Ohyama,Yoshiaki;Zhao,Di;Nwabuo,ChikeC;Post,WendyS;Guallar,Eliseo;Ouyang,Pamela;Shah,SanjivJ;Allison,MatthewA;Ndumele,ChiadiE;Vaidya,Dhananjay;Bluemke,DavidA;Lima,JoaoA;Michos,E
与男性相比，女性经历了与年龄相关的主动脉弹性的急剧下降。在多种族动脉粥样硬化研究中，我们研究了性激素水平是否与升主动脉扩张性（AAD）相关。方法：我们研究了1345名绝经后女性和1532名男性，年龄在45-84岁之间，他们的血清性激素水平、AAD通过心脏磁共振相对比成像测量，基线时射血分数bbb50 %。在这些参与者中，457名女性和548名男性在10年后返回进行后续磁共振成像。按性别分层，并使用混合效应线性回归方法，我们检查了性激素（以位数为单位）与对数转换AAD （mm Hg−110−3）的基线和年变化之间的关系，调整了人口统计学、体型、生活方式因素、平均动脉压、心率、高血压药物使用（在女性中，激素治疗使用和绝经后年限）。结果女性平均（SD）年龄65(9)岁，男性平均（SD）年龄62（10）岁。女性的AAD低于男性（P< 0.001）。在调整后的横断面分析中，女性游离睾酮的最高分位数（与最低分位数相比）与较低的AAD显著相关[- 0.10(- 0.19,- 0.01)]，而男性雌二醇的最高分位数与较高的AAD相关[0.12(0.04,0.20)]。性激素与阿尔茨海默病在10年内的变化没有关联，尽管样本量较小。结论：女性游离睾酮水平较低和男性雌二醇水平较高与基线时主动脉膨大有关，但与纵向无关。性激素水平可能是男女患AAD差异的原因。
BACKGROUNDWomen experience a steeper decline in aortic elasticity related to aging compared to men. We examined whether sex hormone levels were associated with ascending aortic distensibility (AAD) in the Multi-Ethnic Study of Atherosclerosis.METHODSWe studied 1,345 postmenopausal women and 1,532 men aged 45–84 years, who had serum sex hormone levels, AAD measured by phase-contrast cardiac magnetic resonance imaging, and ejection fraction>50% at baseline. Among these participants, 457 women and 548 men returned for follow-up magnetic resonance imaging 10-years later. Stratified by sex, and using mixed effects linear regression methods, we examined associations of sex hormones (as tertiles) with baseline and annual change in log-transformed AAD (mm Hg−110−3), adjusting for demographics, body size, lifestyle factors, mean arterial pressure, heart rate, hypertensive medication use (and in women, for hormone therapy use and years since menopause).RESULTSThe mean (SD) age was 65 (9) for women and 62 (10) years for men. AAD was lower in women than men (P< 0.001). In adjusted cross-sectional analysis, the highest tertile of free testosterone (compared to lowest) in women was significantly associated with lower AAD [−0.10 (−0.19, −0.01)] and the highest tertile of estradiol in men was associated with greater AAD [0.12 (0.04, 0.20)]. There were no associations of sex hormones with change in AAD over 10 years, albeit in a smaller sample size.CONCLUSIONSLower free testosterone in women and higher estradiol in men were associated with greater aortic distensibility at baseline, but not longitudinally. Sex hormone levels may account for differences in AAD between women and men.