Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial
Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial
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DOI：
10.1038/ejcn.2011.59
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发表时间：
2011-08-01
影响因子：
4.7
通讯作者：
Azizi, F.
中科院分区：
文献类型：
--
作者：
Bahadoran, Z.;Mirmiran, P.;Azizi, F.
背景/目的：体外和动物研究已经报道，年轻的西兰花芽改善糖尿病患者的氧化应激状态。这个双盲，安慰剂对照，随机临床试验的目的是调查西兰花芽粉（BSP）对2型糖尿病patients.Subjects/Methods的一些氧化应激参数的影响：共81例2型糖尿病患者被随机分配到三个治疗组之一，为期4周。各组接受10 g/d BSP（n = 27），5 g/d BSP（n = 29）或安慰剂（n = 25）。分别于治疗前和治疗后4周检测血清总抗氧化能力（TAC）、总氧化状态（TOS）、氧化应激指数（OSI）、丙二醛（MDA）和氧化低密度脂蛋白（LDL）胆固醇。结果：三组共63例患者纳入分析：BSP 10 g/d（n = 21）、5 g/d（n = 22）和安慰剂（n = 20）。4周后，摄入BSP导致MDA（治疗效果P = 0.001）、氧化低密度脂蛋白胆固醇（治疗效果P = 0.03）、OSI（治疗效果P 0.001）显著降低，TAC显著增加（治疗效果P 0.001）。结论：BSP对2型糖尿病患者的氧化应激状态有良好的影响。欧洲临床营养学杂志（2011）65，972-977; doi：10.1038/ejcn.2011.59; 2011年5月11日在线发表
Background/Objectives: In vitro and animal studies have reported that young broccoli sprouts improve oxidative stress status in diabetic condition. The objective of this double-blind, placebo-controlled, randomized clinical trial was to investigate the effects of broccoli sprouts powder (BSP) on some oxidative stress parameters in type 2 diabetes patients.Subjects/Methods: A total of 81 patients with type 2 diabetes were randomly assigned to one of three treatment groups for 4 weeks. The groups received either 10 g/d BSP (n = 27), 5 g/d BSP (n = 29) or placebo (n = 25). Serum total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA) and oxidized low density lipoprotein (LDL) cholesterol were measured at baseline and at 4 weeks after treatment.Results: In all, 63 patients in three groups were included in the analysis: 10 g/d BSP (n = 21), 5 g/d (n = 22) and placebo (n = 20). After 4 weeks, consumption of BSP resulted in significant decrease in MDA (P = 0.001 for treatment effect), oxidized low density lipoprotein cholesterol (P = 0.03 for treatment effect), OSI (P 0.001 for treatment effect) and significant increase in TAC (P 0.001 for treatment effect). No effects were found on TOS.Conclusion: BSP had favorable effects on oxidative stress status in type 2 diabetes patients. European Journal of Clinical Nutrition (2011) 65, 972-977; doi:10.1038/ejcn.2011.59; published online 11 May 2011