What Is the Lifetime Risk of Physician-diagnosed Asthma in Ontario, Canada?
What Is the Lifetime Risk of Physician-diagnosed Asthma in Ontario, Canada?
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DOI：
10.1164/rccm.200907-1035oc
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发表时间：
2010-02-15
影响因子：
24.7
通讯作者：
Gershon, Andrea S.
中科院分区：
文献类型：
--
作者：
To, Teresa;Wang, Chengning;Gershon, Andrea S.
理由：哮喘是加拿大最常见的慢性呼吸系统疾病。对哮喘发病风险的估计可以帮助研究人员和卫生规划人员制定研究议程，预测哮喘给社会带来的负担，并针对哮喘高危人群进行预防、管理和控制。目的：评估医生诊断哮喘的终生风险。方法：对1996年4月1日居住在加拿大安大略省的0 ~ 79岁未被诊断为哮喘的个体进行11年的监测，直至2007年3月31日。当他们被诊断患有哮喘、80岁或死亡时，他们会被审查。通过改进的生存分析技术计算医生诊断的哮喘的终生风险（从出生到79岁）。结果按性别、农村和邻里收入分层。测量和主要结果：总体而言，医生诊断哮喘的终生风险为33.9%。尽管女性的总体终生风险较高（35.0% vs. 32.9%; P < 0.001），但男性在早期的累积风险较高。生活在城市地区（34.5%比30.1%,P < 0.001）或低收入社区（最低收入五分位数为35.0%比最高收入五分位数为32.2%,P < 0.001）的个体终生风险更高。结论：我们估计的总体一生风险表明，在加拿大安大略省，每三个人中就有一个在一生中被医生诊断为哮喘。
Rationale: Asthma is the most common chronic respiratory disease in Canada. The estimates of risk of developing asthma may help researchers and health planners set research agendas, predict the burden of asthma on society, and target the at-risk population for asthma prevention, management, and control.Objectives: To estimate the lifetime risk of physician-diagnosed asthma.Methods: All individuals aged 0-79 years living in Ontario, Canada on April 1, 1996 who had not been diagnosed with asthma were monitored for 11 years until March 31, 2007. They were censored when they were diagnosed with asthma, turned age 80 years, or died. The lifetime risk (from birth to age 79 yr) of physician-diagnosed asthma was calculated by a modified survival analysis technique. Results were stratified by sex, rurality, and neighborhood income.Measurements and Main Results: Overall, the lifetime risk of physician-diagnosed asthma was 33.9%. Whereas the overall lifetime risk was higher in females (35.0 vs. 32.9%; P < 0.001), the cumulative risk was higher in males in early years. The lifetime risk was higher in individuals living in urban areas (34.5 vs. 30.1%; P < 0.001) or low-income neighborhoods (35.0% in the lowest income quintile vs. 32.2% in the highest; P < 0.001).Conclusions: Our estimated overall lifetime risk indicates that one of every three individuals in Ontario, Canada has physician-diagnosed asthma during one's lifetime.