Recurrence of pericarditis after influenza vaccination: a case report and review of the literature.

Recurrence of pericarditis after influenza vaccination: a case report and review of the literature.
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DOI:
10.1186/s40360-018-0211-8
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发表时间:
2018-05-05
影响因子:
2.9
通讯作者:
De Ponti F
De Ponti F
中科院分区:
医学4区
文献类型:
--
作者:
Mei R;Raschi E;Poluzzi E;Diemberger I;De Ponti F

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本病例报告描述了一例可能归因于流感疫苗接种(再激发阳性)的心包炎患者,并进行了文献综述。1例87岁患者在接种流感疫苗后发生心包炎,伴急性胸痛,无心电图异常或心肌酶水平升高。超声心动图显示中度心包积液。通过类固醇获得恢复一年后,再次免疫后几天,患者出现相同的症状,并被诊断为心包炎复发伴严重心包积液而入院,再次接受类固醇治疗。排除了其他可能的原因,心脏病专家建议将来不要接种流感疫苗;患者在随后6年内未发生心包炎复发。我们也回顾了文献中流感疫苗接种后发生心包炎的病例。流感疫苗接种后发生心包炎在文献中很少报道。在少数情况下,流感疫苗接种似乎是罪魁祸首。我们建议考虑近期免疫接种的病人的历史,作为鉴别诊断的一部分,老年胸痛。
This case report describes a patient with pericarditis likely attributed to influenza vaccination (positive rechallenge), with a literature review. A 87-year old patient developed pericarditis after influenza vaccination, with acute chest pain, without ECG abnormalities or increased cardiac enzyme levels. Echocardiogram showed moderate pericardial effusion. Recovery was obtained through steroids One year later, few days after re-immunization, the patient experienced the same symptoms and was admitted to hospital with diagnosis of recurrence of pericarditis with severe pericardial effusion, again treated with steroids. Other possible causes were ruled out and the cardiologist recommended against influenza vaccinations in the future; the patient did not experience recurrence of pericarditis in the following 6 years. Cases of pericarditis following influenza immunization in the literature were also reviewed. Pericarditis following immunization for influenza is very rarely reported in the literature. In a few cases, influenza vaccination seems likely responsible. We suggest considering recent immunization in patient’s history as part of the differential diagnosis in elderly with chest pain.
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