Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria.
Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria.
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DOI：
10.1016/j.redox.2014.12.011
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发表时间：
2015
期刊：
影响因子：
11.4
通讯作者：
Yin H
中科院分区：
文献类型：
--
作者：
Zhong H;Yin H
氧化应激诱导的脂质过氧化与人体生理和包括癌症在内的疾病有关。大量数据表明，在这一过程中产生的反应性脂质介质，如4-羟基壬烯醛(4-HNE)，是氧化应激的生物标志物，在许多信号通路中发挥重要作用。4-HNE的生物学效应主要是通过蛋白质、DNA和含氨基的磷脂等重要生物分子的共价修饰来实现的。本文综述了4-HNE在肿瘤发病机制中作用的最新研究进展，重点介绍了线粒体的参与：线粒体特异性磷脂的氧化生成4-HNE；线粒体蛋白质、脂类和DNA的共价修饰；针对线粒体ROS生成、脂质过氧化和4-HNE的潜在治疗策略。
Oxidative stress-induced lipid peroxidation has been associated with human physiology and diseases including cancer. Overwhelming data suggest that reactive lipid mediators generated from this process, such as 4-hydroxynonenal (4-HNE), are biomarkers for oxidative stress and important players for mediating a number of signaling pathways. The biological effects of 4-HNE are primarily due to covalent modification of important biomolecules including proteins, DNA, and phospholipids containing amino group. In this review, we summarize recent progress on the role of 4-HNE in pathogenesis of cancer and focus on the involvement of mitochondria: generation of 4-HNE from oxidation of mitochondria-specific phospholipid cardiolipin; covalent modification of mitochondrial proteins, lipids, and DNA; potential therapeutic strategies for targeting mitochondrial ROS generation, lipid peroxidation, and 4-HNE.