An efficient F-18 labeling method for PET study: Huisgen 1,3-dipolar cycloaddition of bioactive substances and F-18-labeled compounds
An efficient F-18 labeling method for PET study: Huisgen 1,3-dipolar cycloaddition of bioactive substances and F-18-labeled compounds
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DOI：
10.1016/j.tetlet.2007.04.048
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发表时间：
2007-06-04
影响因子：
1.8
通讯作者：
Chi, Dae Yoon
中科院分区：
文献类型：
--
作者：
Sirion, Uthaiwan;Kim, Hee Jun;Chi, Dae Yoon
将Cu（I）催化的1，3-偶极环加成反应成功地应用于F-18标记的生物小分子的合成，并开发了一锅两步反应的最佳条件，无需任何中间纯化。该技术被用于各种F-18标记的1，2，3-三唑合成，具有高放射化学产率。(c)2007爱思唯尔有限公司保留所有权利。
The Cu(I)-catalyzed, 1,3-dipolar cycloaddition reaction was applied successfully to the synthesis of small, F-18-labeled biomolecules, and an optimal condition was developed for one-pot, two-step reaction without any interim purifications. This technique was employed in various F-18-labeled, 1,2,3-triazole syntheses with high radiochemical yield. (c) 2007 Elsevier Ltd. All rights reserved.