NEW BENZ[A]ANTHRAQUINONE SECONDARY METABOLITES FROM STREPTOMYCES PHAEOCHROMOGENES
NEW BENZ[A]ANTHRAQUINONE SECONDARY METABOLITES FROM STREPTOMYCES PHAEOCHROMOGENES
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DOI：
10.1021/jo00081a020
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发表时间：
1994-01-28
影响因子：
3.6
通讯作者：
CHENG, XC
中科院分区：
文献类型：
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作者：
GOULD, SJ;CHENG, XC
从嗜铬链霉菌WP 3688中分离到4个与苯并[a]蒽醌类抗生素PD 116198有关的新的苯并[a]蒽醌类代谢物，并对其进行了结构鉴定。其中两个与PD 116198具有很强的结构相似性，而另外两个则不太相似，并具有新的氧化骨架。通过NOE和NOESY差谱分析，获得了这些代谢产物的相对立体化学。
Four new benz[a] anthraquinone metabolites related to PD 116198, a known benz[a] anthraquinone antibiotic, were isolated from Streptomyces phaeochromogenes WP 3688 and characterized. Two showed strong structural similarities with PD 116198, while two others were less similar and possessed novel oxidized skeletons. The relative stereochemistry of these metabolites was obtained by analysis of difference NOE and NOESY spectra.