Urban Leptospirosis in Africa: A Cross-Sectional Survey of Leptospira Infection in Rodents in the Kibera Urban Settlement, Nairobi, Kenya
Urban Leptospirosis in Africa: A Cross-Sectional Survey of Leptospira Infection in Rodents in the Kibera Urban Settlement, Nairobi, Kenya
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DOI：
10.4269/ajtmh.13-0415
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发表时间：
2013-12-01
影响因子：
3.3
通讯作者：
Breiman, Robert F.
中科院分区：
文献类型：
--
作者：
Halliday, Jo E. B.;Knobel, Darryn L.;Breiman, Robert F.
钩端螺旋体病是一种普遍但报道不足的发病和死亡原因。钩端螺旋体病在全球重新出现与非正式城市住区的增长有关，其中啮齿动物被认为是重要的水库宿主。了解钩端螺旋体病的多宿主流行病学对控制和预防疾病至关重要。2008年9月至10月，在肯尼亚内罗毕的基贝拉定居点进行了一项啮齿动物横断面调查，以证明致病性钩端螺旋体的存在。实时定量聚合酶链反应显示，224只啮齿动物中有41只（18.3%）的肾脏携带致病性钩端螺旋体，序列数据鉴定为问号钩端螺旋体和钩端螺旋体。kirschneri在这个人群中。小鼠属啮齿动物（37/185）比鼠属啮齿动物（4/39;比值比= 15.03）更可能呈阳性。问卷调查数据显示，基贝拉人与啮齿动物之间经常接触。这项研究强调，需要量化这种被忽视的疾病在这个和非洲其他城市网站的公共卫生影响。
Leptospirosis is a widespread but under-reported cause of morbidity and mortality. Global re-emergence of leptospirosis has been associated with the growth of informal urban settlements in which rodents are thought to be important reservoir hosts. Understanding the multi-host epidemiology of leptospirosis is essential to control and prevent disease. A cross-sectional survey of rodents in the Kibera settlement in Nairobi, Kenya was conducted in September-October 2008 to demonstrate the presence of pathogenic leptospires. A real-time quantitative polymerase chain reaction showed that 41 (18.3%) of 224 rodents carried pathogenic leptospires in their kidneys, and sequence data identified Leptospira interrogans and L. kirschneri in this population. Rodents of the genus Mus (37 of 185) were significantly more likely to be positive than those of the genus Rattus (4 of 39; odds ratio = 15.03). Questionnaire data showed frequent contact between humans and rodents in Kibera. This study emphasizes the need to quantify the public health impacts of this neglected disease at this and other urban sites in Africa.