TRANSPORT PROPERTIES OF CARTILAGINOUS TISSUES.
TRANSPORT PROPERTIES OF CARTILAGINOUS TISSUES.
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DOI：
10.2174/157339709787315320
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发表时间：
2009-02-01
影响因子：
1.5
通讯作者：
Gu W
中科院分区：
文献类型：
--
作者：
Jackson A;Gu W
软骨组织，如关节软骨和椎间盘，是无血管组织，其依赖于细胞营养的运输。因此，在这些组织中的运输特性的综合知识是必要的，在理解营养供应的细胞。此外，软骨组织中细胞营养不良被认为是组织变性的主要来源，这可能导致骨关节炎（OA）或椎间盘变性。在这篇简短的综述中，我们对软骨组织中的传输特性和行为的研究现状进行了概述。在这些组织中的运输机制，以及实验方法来测量运输性能和获得的结果进行了讨论。介绍了软骨组织工程中生物反应器的研究现状。
Cartilaginous tissues, such as articular cartilage and intervertebral disc, are avascular tissues which rely on transport for cellular nutrition. Comprehensive knowledge of transport properties in such tissues is therefore necessary in the understanding of nutritional supply to cells. Furthermore, poor cellular nutrition in cartilaginous tissues is believed to be a primary source of tissue degeneration, which may result in osteoarthritis (OA) or disc degeneration. In this mini-review, we present an overview of the current status of the study of transport properties and behavior in cartilaginous tissues. The mechanisms of transport in these tissues, as well as experimental approaches to measuring transport properties and results obtained are discussed. The current status of bioreactors used in cartilage tissue engineering is also presented.