Sterol-regulatory-element-binding protein 1c mediates insulin action on hepatic gene expression.
Sterol-regulatory-element-binding protein 1c mediates insulin action on hepatic gene expression.
复制标题
甾醇调节元件结合蛋白 1c 介导胰岛素对肝基因表达的作用。
DOI：
--
复制
发表时间：
2001
影响因子：
3.9
通讯作者：
F. Foufelle
中科院分区：
文献类型：
--
作者：
Pascal Ferré;Marc Foretz;Dalila Azzout;D. Bécard;F. Foufelle
胰岛素对肝脏特异性基因表达的影响是哺乳动物维持能量稳态的适应性机制的一部分。当饮食富含碳水化合物时，分泌的胰岛素会刺激参与葡萄糖利用的酶基因（葡萄糖激酶、L型丙酮酸激酶和脂肪生成酶）的表达，并抑制参与葡萄糖生成的酶基因（磷酸酚丙酮酸羧激酶）的表达。人们对胰岛素控制这些基因表达的机制知之甚少。最近，转录因子甾醇调节元件结合蛋白 1c 被认为是胰岛素转录作用的关键介质。在这里，我们回顾了导致这一提议的证据，以及我们理解胰岛素在生理或病理条件下的作用的后果。
Effects of insulin on the expression of liver-specific genes are part of the adaptive mechanisms aimed at maintaining energy homeostasis in mammals. When the diet is rich in carbohydrates, secreted insulin stimulates the expression of genes for enzymes involved in glucose utilization (glucokinase, L-type pyruvate kinase and lipogenic enzymes) and inhibits genes for enzymes involved in glucose production (phosphenolpyruvate carboxykinase). The mechanisms by which insulin controls the expression of these genes have been poorly understood. Recently, the transcription factor sterol-regulatory-element-binding protein 1c has been proposed as a key mediator of insulin transcriptional effects. Here we review the evidence that has led to this proposal and the consequences for our understanding of insulin effects in physiological or pathological conditions.