Small heat shock protein expression and functions during development
Small heat shock protein expression and functions during development
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DOI：
10.1016/j.biocel.2012.03.009
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发表时间：
2012-10-01
影响因子：
4
通讯作者：
Tanguay, Robert M.
中科院分区：
文献类型：
--
作者：
Morrow, Genevieve;Tanguay, Robert M.
在多种生物的发育过程中，小分子热休克蛋白的表达受到严格的调控。作为看家蛋白，小分子热休克蛋白有助于保护细胞免于凋亡，稳定细胞骨架，并有助于蛋白稳定。一贯地，一个小的热休克蛋白的耗尽通常是无害的，因为每个小的热休克蛋白的功能之间存在一定程度的冗余。然而，虽然它们在胁迫诱导下的表达受到热休克因子的调控，但它们的结构性表达受到其他特定转录因子的控制，这表明它们存在非常特殊的功能。本文就小分子热休克蛋白在各种生物发育过程中的表达模式和功能作一综述。本文是题为：生理学和病理学中的小热休克蛋白的定向问题的一部分。(C)2012爱思唯尔有限公司。保留所有权利。
The expression of small heat shock proteins is tightly regulated during development in multiple organisms. As housekeeping proteins, small heat shock proteins help protect cells from apoptosis, stabilize the cytoskeleton and contribute to proteostasis. Consistently, depletion of one small heat shock protein is usually not detrimental due to a certain level of redundancy between the functions of each small heat shock protein. However, while their stress-induced expression is regulated by heat shock factors, their constitutive expression is under the control of other specific transcription factors, suggesting the existence of very specialized functions. This review focuses on the expression patterns and functions of small heat shock proteins in various organisms during development. This article is part of a Directed Issue entitled: Small HSPs in physiology and pathology. (C) 2012 Elsevier Ltd. All rights reserved.