Fetal programming of the neuroendocrine-immune system and metabolic disease.
Fetal programming of the neuroendocrine-immune system and metabolic disease.
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DOI：
10.1155/2012/792934
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发表时间：
2012
影响因子：
3.2
通讯作者：
Karrow NA
中科院分区：
文献类型：
--
作者：
Fisher RE;Steele M;Karrow NA
胎儿发育期间经历的不利子宫环境会改变身体各种器官和系统的预期生长模式，使后代患代谢疾病的风险增加。节俭表型假说已被证明是一种改变生长轨迹，以提高个体的生存和生殖适应性。然而，当子宫内环境与子宫外环境不匹配时，可能会出现问题。随着西方化国家和发展中国家代谢性疾病的增加，子宫外环境与环境的脱节变得越来越明显。因此，本文的重点将是探讨母亲营养不良对后代的代谢紊乱，如肥胖，心血管疾病和糖尿病的易感性的影响，重点是编程的神经内分泌免疫系统。
Adverse uterine environments experienced during fetal development can alter the projected growth pattern of various organs and systems of the body, leaving the offspring at an increased risk of metabolic disease. The thrifty phenotype hypothesis has been demonstrated as an alteration to the growth trajectory to improve the survival and reproductive fitness of the individual. However, when the intrauterine environment does not match the extrauterine environment problems can arise. With the increase in metabolic diseases in both Westernized and developing countries, it is becoming apparent that there is an environmental disconnect with the extrauterine environment. Therefore, the focus of this paper will be to explore the effects of maternal malnutrition on the offspring's susceptibility to metabolic disorders such as obesity, cardiovascular disease, and diabetes with emphasis on programming of the neuroendocrine-immune system.