Human clinical trial to assess the effect of consumption of multigrain Indian bread on glycemic regulation in type 2 diabetic participants
Human clinical trial to assess the effect of consumption of multigrain Indian bread on glycemic regulation in type 2 diabetic participants
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DOI：
10.1111/jfbc.13465
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发表时间：
2020-10-01
影响因子：
4
通讯作者：
Korrapati, Damayanti
中科院分区：
文献类型：
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作者：
Sobhana, Prasanthi Prabhakaran;Kandlakunta, Bhaskarachary;Korrapati, Damayanti
在100例2型糖尿病患者中研究了杂粮大饼在调节2型糖尿病患者血脂和碳水化合物稳态方面的疗效。结果显示，人体测量参数在试验组和对照组中均保持不变。空腹血糖水平（140.70 +/- 8.43 vs 132.89 +/- 5.63 mg/dl）未显著降低。相比之下，试验组的胰岛素水平（12.96 +/- 1.06 vs 10.83 +/- 1.03 mu IU/ml）和HbA 1c水平（8.01 +/- 0.27 vs 7.40 +/- 0.21%）显著降低，并且与胰岛素抵抗降低相关。干预后，试验组的LDL水平下降（116.0 +/- 5.67 vs 98.7 +/- 5.68 mg/dl），而甘油三酯和VLDL显著增加，HDL水平保持不变。在试验组参与者中观察到平均血压（收缩压/舒张压）显著降低。人RBP 4和hs-CRP保持不变。实际应用小米含有丰富的纤维、复杂的碳水化合物、蛋白质，脂肪含量较低。小米提供了广泛的营养素，植物化学物质，并且是无麸质的低血糖性质。它们的摄入量可以减少胰岛素抵抗和氧化应激等因素，这些因素是2型糖尿病和心血管疾病的发病机制。我们的研究表明，使用由小米制成的杂粮扁平面包有助于降低血清胰岛素，LDL胆固醇，HbA 1c水平，顺便说一句，2型糖尿病参与者的胰岛素敏感性显著增加。研究结果表明，在血糖控制和胰岛素敏感性方面，使用杂粮大饼作为糖尿病患者的食物补充剂或膳食补充剂。
The efficacy of multigrain flatbread in regulating the lipid profile and carbohydrate homeostasis among type 2 diabetic patients was studied in 100 type 2 diabetic participants. The results revealed that the anthropometric parameters remained unaltered in both test and control groups. The fasting blood glucose levels (140.70 +/- 8.43 versus 132.89 +/- 5.63 mg/dl) did not significantly decrease. In contrast, the insulin levels (12.96 +/- 1.06 versus 10.83 +/- 1.03 mu IU/ml) and HbA1c levels (8.01 +/- 0.27 versus 7.40 +/- 0.21%) in the test group decreased significantly, and it was associated with a decrease in insulin resistance. The LDL levels in the test group decreased after the intervention (116.0 +/- 5.67 versus 98.7 +/- 5.68 mg/dl), while triglycerides and VLDL increased significantly and HDL levels remained unaltered. A significant decrease in average blood pressure (systolic/diastolic) was noticed among the test group participants. The human RBP4 and hs-CRP remained unaltered. Practical applications Millets are rich in fibers, has complex carbohydrate, protein, and is lower in fat content. Millets provide a wide range of nutrients, phytochemicals, and are gluten-free with low glycemic nature. Their intake can reduce factors such as insulin resistance and oxidative stress responsible for the pathogenesis of type 2 diabetes and cardiovascular diseases. Our study indicated the use of multigrain flatbreads prepared from millets helped reduce serum insulin, LDL cholesterol, HbA1c levels, and incidentally blood pressure levels with a significant increase in insulin sensitivity in type 2 diabetes participants. The results suggest using the multigrain flatbread meal as a food supplement or meal replacer in diabetic participants in terms of glucose control and insulin sensitivity.