Characterization and modeling of P-type electrosensory afferent responses to amplitude modulations in a wave-type electric fish
Characterization and modeling of P-type electrosensory afferent responses to amplitude modulations in a wave-type electric fish
复制标题
DOI：
10.1007/s003590050137
复制
发表时间：
1997-11
期刊：
影响因子：
--
通讯作者：
Mark E. Nelson;Zhian Xu;J. Payne
中科院分区：
文献类型：
--
作者：
Mark E. Nelson;Zhian Xu;J. Payne
电感觉系统中信息处理的第一阶段涉及将经皮电位的局部变化编码为初级电感觉传入神经纤维中的动作电位序列。要开发一个定量模型，这种编码过程的P型（概率编码）传入纤维在弱电鱼类Apteronotus leptorhynchus，我们记录了单个单位的活动，从电感觉传入轴突的后分支的前侧线神经和分析响应电子产生的正弦振幅调制的局部经皮电位。在0.1至200 Hz的AM频率范围内，P型传入神经的调制传递函数具有高通特性，其增益单调增加直至100 Hz的AM频率，在100 Hz处其开始滚降，并且相位提前范围为15-60度。定量分析所观察到的增益和相位特性的基础上，我们提出了一个计算有效的模型的P型传入反应动力学，准确地表征传入放电率的变化，响应于振幅调制的鱼的自己的电器官放电在很宽的范围内的AM频率相关的主动电定位。
The first stage of information processing in the electrosensory system involves the encoding of local changes in transdermal potential into trains of action potentials in primary electrosensory afferent nerve fibers. To develop a quantitative model of this encoding process for P-type (probability-coding) afferent fibers in the weakly electric fishApteronotus leptorhynchus, we recorded single unit activity from electrosensory afferent axons in the posterior branch of the anterior lateral line nerve and analyzed responses to electronically generated sinusoidal amplitude modulations of the local transdermal potential. Over a range of AM frequencies from 0.1 to 200 Hz, the modulation transfer function of P-type afferents is high-pass in character, with a gain that increases monotonically up to AM frequencies of 100 Hz where it begins to roll off, and a phase advance with a range of 15–60 degrees. Based on quantitative analysis of the observed gain and phase characteristics, we present a computationally efficient model of P-type afferent response dynamics which accurately characterizes changes in afferent firing rate in response to amplitude modulations of the fish's own electric organ discharge over a wide range of AM frequencies relevant to active electrolocation.