HIV and syphilis co-infection increasing among men who have sex with men in China: a systematic review and meta-analysis.
HIV and syphilis co-infection increasing among men who have sex with men in China: a systematic review and meta-analysis.
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DOI：
10.1371/journal.pone.0022768
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Chow EP;Wilson DP;Zhang L
本研究通过对已发表文献的系统回顾，对2003年至2008年中国地区男男性接触者中艾滋病病毒、梅毒及混合感染的程度和变化趋势进行评估。检索2003-2008年间男男性接触者中HIV和梅毒流行情况的中文和英文文献。通过Meta分析对患病率估计值进行总结和分析。Meta回归被用来确定与Meta分析中高异质性相关的潜在因素。本综述共筛选出符合条件的文献71篇(英文17篇，中文54篇)。在全国范围内，男男性接触者的艾滋病毒流行率从2003-2004年的1.3%上升到2005-2006年的2.4%，2007-2008年上升到4.7%。梅毒患病率从2003-2004年的6.8%上升到2005-2006年的10.4%，2007-2008年上升到13.5%。艾滋病毒和梅毒合并感染从2005-2006年的1.4%上升到2007-2008年的2.7%。研究地点和研究年限是造成中国男男性接触者HIV和梅毒流行异质性的两个主要因素。中国地区男男性接触者艾滋病、梅毒感染率明显上升。扩大艾滋病毒和梅毒筛查，并实施有效的公共卫生干预计划，应针对男男性接触者，以防止艾滋病毒和梅毒感染的进一步传播。
This study aims to estimate the magnitude and changing trends of HIV, syphilis and HIV-syphilis co-infections among men who have sex with men (MSM) in China during 2003–2008 through a systematic review of published literature. Chinese and English literatures were searched for studies reporting HIV and syphilis prevalence among MSM from 2003 to 2008. The prevalence estimates were summarized and analysed by meta-analyses. Meta-regression was used to identify the potential factors that are associated with high heterogeneities in meta-analysis. Seventy-one eligible articles were selected in this review (17 in English and 54 in Chinese). Nationally, HIV prevalence among MSM increased from 1.3% during 2003–2004 to 2.4% during 2005–2006 and to 4.7% during 2007–2008. Syphilis prevalence increased from 6.8% during 2003–2004 to 10.4% during 2005–2006 and to 13.5% during 2007–2008. HIV-syphilis co-infection increased from 1.4% during 2005–2006 to 2.7% during 2007–2008. Study locations and study period are the two major contributors of heterogeneities of both HIV and syphilis prevalence among Chinese MSM. There have been significant increases in HIV and syphilis prevalence among MSM in China. Scale-up of HIV and syphilis screening and implementation of effective public health intervention programs should target MSM to prevent further spread of HIV and syphilis infection.