PAIN-REDUCING PROPERTIES OF SUCROSE IN HUMAN NEWBORNS
PAIN-REDUCING PROPERTIES OF SUCROSE IN HUMAN NEWBORNS
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DOI：
10.1093/chemse/20.1.29
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发表时间：
1995-02-01
期刊：
影响因子：
3.5
通讯作者：
SHAH, A
中科院分区：
文献类型：
--
作者：
BLASS, EM;SHAH, A
为了评估蔗糖作为止痛物质的特性，测定了72名新生儿在通过足跟穿刺采血期间和之后的哭泣。在第一项研究中，婴儿在采血前1分钟饮用2 ml水或2 ml 0.77 - 0.34或0.51-M蔗糖溶液。在第二个实验中，在蔗糖摄入和开始采血之间施加30、60、90、120或240 s的延迟。浓度的剂量反应函数是平坦的。最有效的时间延迟为120 s。2分钟间隔的有效性符合之前关于蔗糖味道引起的内源性阿片类药物释放的发现。平坦的剂量-反应函数扩展了在大鼠和人类中的发现，即蔗糖的镇静和减轻疼痛的作用不受浓度或体积的影响，这表明从味觉传入到阿片类药物介导的传出的转导具有开-关性质并且不分级。
To assess the characteristics of sucrose as a pain-reducing substance, crying in 72 newborn humans during and after blood collection via heel prick was determined. In the first study infants drank 2 ml of water or 2 ml of a 0.770.34- or 0.51-M sucrose solution 1 min prior to blood collection. In the second experiment, a delay of 30, 60, 90, 120 or 240 s was imposed between sucrose intake and the initiation of blood collection. The dose-response function for concentration was flat. The most effective time delay was 120 s. The effectiveness of the 2-min interval accords with previous findings of endogenous opioid release caused by sucrose taste. The flat dose-response function extends findings in rats and humans that the calming and pain-reducing effects of sucrose are not influenced by either concentration or volume, suggesting that the transduction from gustatory afferent to opioid-mediated efferent is of an on-off nature and not graded.