Energy Metabolism of Bone.
Energy Metabolism of Bone.
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骨骼的能量代谢。
DOI：
10.1177/0192623317737065
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发表时间：
2017-10
影响因子：
1.5
通讯作者：
Rosen CJ
中科院分区：
文献类型：
--
作者：
Motyl KJ;Guntur AR;Carvalho AL;Rosen CJ
生物过程利用能源，因此必须根据燃料的可用性确定优先次序。骨骼也不例外，必要时重塑的好处超过了能量成本。骨重建对于维持血钙稳态、修复微裂纹和骨折以及修改骨结构以使其更好地适应负荷需求是重要的。破骨细胞、成骨细胞和骨细胞是负责骨重建的主要细胞，尽管骨髓脂肪细胞和其他细胞也可能发挥间接作用。骨细胞能量学重新引起人们的兴趣，因为这些过程有可能成为骨质疏松症治疗的目标。相反，由于骨和能量稳态之间的密切联系，治疗代谢疾病或具有代谢副作用的药物通常具有有害的骨后果。在这篇简短的综述中，我们将介绍骨质疏松症，讨论骨细胞如何利用能量发挥作用，骨调节全身能量稳态的证据，以及一些未回答的问题和该领域进一步研究的机会。
Biological processes utilize energy and therefore must be prioritized based on fuel availability. Bone is no exception to this, and the benefit of remodeling when necessary outweighs the energy costs. Bone remodeling is important for maintaining blood calcium homeostasis, repairing micro cracks and fractures, and modifying bone structure so that it is better suited to withstand loading demands. Osteoclasts, osteoblasts and osteocytes are the primary cells responsible for bone remodeling, although bone marrow adipocytes and other cells may also play an indirect role. There is a renewed interest in bone cell energetics because of the potential for these processes to be targeted for osteoporosis therapies. In contrast, due to the intimate link between bone and energy homeostasis, pharmaceuticals that treat metabolic disease or have metabolic side effects often have deleterious bone consequences. In this brief review, we will introduce osteoporosis, discuss how bone cells utilize energy to function, evidence for bone regulating whole body energy homeostasis, and some of the unanswered questions and opportunities for further research in the field.