Cell-matrix and cell-cell interaction mechanics in guiding migration.
Cell-matrix and cell-cell interaction mechanics in guiding migration.
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DOI：
10.1042/bst20230211
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发表时间：
2023-08-31
影响因子：
3.9
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中科院分区：
文献类型：
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组织的物理特性越来越被认为是影响细胞行为（特别是细胞迁移）的主要调控因素。尽管细胞外基质的这些特性已被广泛讨论，但构成组织的细胞成分的贡献仍然知之甚少。在这篇简短的评论中，我们将讨论两个主要的物理组成部分：刚度和拓扑结构，重点关注细胞与细胞之间的相互作用以及它们如何影响细胞迁移。
Physical properties of tissue are increasingly recognised as major regulatory cues affecting cell behaviours, particularly cell migration. While these properties of the extracellular matrix have been extensively discussed, the contribution from the cellular components that make up the tissue are still poorly appreciated. In this mini-review, we will discuss two major physical components: stiffness and topology with a stronger focus on cell–cell interactions and how these can impact cell migration.