The anaphase-promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions
The anaphase-promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions
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DOI：
10.1042/bst0380065
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发表时间：
2010-02-01
影响因子：
3.9
通讯作者：
Malumbres, Marcos
中科院分区：
文献类型：
--
作者：
Manchado, Eusebio;Eguren, Manuel;Malumbres, Marcos
APC/C（后期促进复合体/环体）是一种E3泛素连接酶，针对26S蛋白酶体降解的特定底物。APC/C活性取决于两个辅助因子，即Cdc20（细胞分裂周期20）和Cdh1，它们选择合适的靶点进行泛素化。APC/C是有丝分裂过程中纺锤体组装检查点（SAC）的靶标，在控制有丝分裂和DNA复制的主要调节因子的蛋白质水平方面起着关键作用。此外，最近的研究表明APC/C在非有丝分裂细胞中具有新的细胞周期无关的功能，特别是在神经元结构和功能中。考虑到APC/C在细胞增殖和神经元生理中的相关功能，调节APC/C活性可能在临床中有有益的作用。
The APC/C (anaphase-promoting complex/cyclosome) is an E3 ubiquitin ligase that targets specific substrates for degradation by the 26S proteasome. APC/C activity depends on two cofactors, namely Cdc20 (cell division cycle 20) and Cdh1, which select the appropriate targets for ubiquitination. it is well established that APC/C is a target of the SAC (spindle assembly checkpoint) during mitosis and has critical roles in controlling the protein levels of major regulators of mitosis and DNA replication. in addition, recent studies have suggested new cell-cycle-independent functions of APC/C in non-mitotic cells and specifically in neuronal structure and function. Given the relevant functions of APC/C in cell proliferation and neuronal physiology, modulating APC/C activity may have beneficial effects in the clinic.