Do Non-collagenous Proteins Affect Skeletal Mechanical Properties?
Do Non-collagenous Proteins Affect Skeletal Mechanical Properties?
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DOI：
10.1007/s00223-015-0016-3
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发表时间：
2015-09
影响因子：
4.2
通讯作者：
Vashishth D
中科院分区：
文献类型：
--
作者：
Morgan S;Poundarik AA;Vashishth D
骨的显著机械性能归因于其复杂的纳米复合材料结构，除了矿物质和胶原之外，还包括各种非胶原基质蛋白或NCP。传统上，NCPs已被研究为生物过程中的信号分子，包括骨形成，吸收和转换。有限的注意力已经给予他们的作用，在确定骨的机械性能。最近的研究强调，NCP确实可以随着衰老，疾病和药物治疗而丢失或修改。关键NCP的纯合子和杂合子小鼠模型提供了一种有用的方法来确定NCP对骨形态学以及基质质量的影响，并进行详细的力学分析，以阐明NCP影响骨力学性能的途径。在这篇文章中，我们提出了一个系统的分析一个大的队列的NCP骨的结构和材料的层次结构，并确定三个主要途径，他们确定骨的力学性能。这些途径包括对骨结构能力至关重要的骨形态参数的改变、关键基质参数（矿物质和胶原）的骨质量变化以及作为承重结构蛋白的直接作用。
The remarkable mechanical behavior of bone is attributed to its complex nanocomposite structure that, in addition to mineral and collagen, comprises a variety of non-collagenous matrix proteins or NCPs. Traditionally, NCPs have been studied as signaling molecules in biological processes including bone formation, resorption and turnover. Limited attention has been given to their role in determining the mechanical properties of bone. Recent studies have highlighted that NCPs can indeed be lost or modified with aging, diseases and drug therapies. Homozygous and heterozygous mice models of key NCP provide a useful approach to determine the impact of NCPs on bone morphology as well as matrix quality, and to carry out detailed mechanical analysis for elucidating the pathway by which NCPs can affect the mechanical properties of bone. In this article, we present a systematic analysis of a large cohort of NCPs on bone’s structural and material hierarchy, and identify three principal pathways by which they determine bone’s mechanical properties. These pathways include alterations of bone morphological parameters crucial for bone’s structural competency, bone quality changes in key matrix parameters (mineral and collagen), and a direct role as load bearing structural proteins.