THE ROLE OF CYTOKINES IN HEAT-STROKE
THE ROLE OF CYTOKINES IN HEAT-STROKE
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DOI：
10.3109/08820139309084183
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发表时间：
1993-01-01
影响因子：
2.8
通讯作者：
CHANG, DM
中科院分区：
文献类型：
--
作者：
CHANG, DM
中暑是一种以发高烧为特征的疾病。细胞因子如白细胞介素-1（IL-1）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-部分衍生物）在发热中起主要作用。在目前的研究中，8例中暑患者参加了细胞因子研究。这些患者的血清细胞因子水平测定EIA方法，并在体外IL-1和IL-1抑制剂的生产测定小鼠胸腺细胞增殖试验和/或EIA。循环IL-1、TNF-偏衍生物和IL-6水平显著升高。体温与IL-1 β水平呈正相关，降温时间与血清IL-1 β水平呈正相关。此外，中暑患者完全恢复后的单核细胞分泌的IL-1的量比正常志愿者高得多。然而，IL-1抑制剂的产生没有差异。这些结果表明，细胞因子可能在中暑的发病机制中起着重要作用，并且能够使不同数量的IL-1响应于外源性刺激似乎是中暑发作的危险因素。
Heat stroke is a disease characterized by high fever. Cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-partial derivative) play a major role in fever production. In the current studies, eight patients with heat stroke were enrolled in a cytokine studies. Serum cytokine levels of these patients were determined by EIA methods, and in vitro IL-1 and IL-1 inhibitor production were determined by murine thymocyte proliferation assay and/or EIA. Significantly high levels of circulating IL-1, TNF-partial derivative, and IL-6 were demonstrated. Positive correlations were demonstrated between the body temperature and the level of IL-1 beta, and the cooling time and level of serum IL-1 beta. In addition, monocytes from heat stroke patients after complete recovery, secreted a much higher amount of IL-1 than did normal volunteers. However, there was no difference in IL-1 inhibitor production. These results indicate that cytokines may play a major role in the pathogenesis of heat stroke, and the ability to make different amounts of IL-1 in response to exogenous stimulation appear to be risk factors for an attack of heat stroke.