Tricellular junctions: how to build junctions at the TRICkiest points of epithelial cells.
Tricellular junctions: how to build junctions at the TRICkiest points of epithelial cells.
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DOI：
10.1091/mbc.e16-10-0697
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发表时间：
2017-07-15
影响因子：
3.3
通讯作者：
Miller AL
中科院分区：
文献类型：
--
作者：
Higashi T;Miller AL
三细胞接触是三个细胞相遇的地方。在脊椎动物上皮细胞中，已经鉴定了称为三细胞紧密连接（tTJ）和三细胞粘附连接（tAJs）的专门结构。tTJ对于屏障功能的维持是重要的，并且tTJ蛋白的破坏有助于家族性耳聋。tAJs最近引起了机械生物学家的注意，因为这些部位是上皮张力的热点。虽然tTJ和tAJs以及无脊椎动物三细胞连接的分子组成、调节和功能开始被表征，但仍存在许多问题。在这里，我们广泛地涵盖了什么是已知的三细胞连接，提出了一个新的模型，在tAJs的张力传输，并讨论关键的开放问题。
Tricellular contacts are the places where three cells meet. In vertebrate epithelial cells, specialized structures called tricellular tight junctions (tTJs) and tricellular adherens junctions (tAJs) have been identified. tTJs are important for the maintenance of barrier function, and disruption of tTJ proteins contributes to familial deafness. tAJs have recently been attracting the attention of mechanobiologists because these sites are hot spots of epithelial tension. Although the molecular components, regulation, and function of tTJs and tAJs, as well as of invertebrate tricellular junctions, are beginning to be characterized, many questions remain. Here we broadly cover what is known about tricellular junctions, propose a new model for tension transmission at tAJs, and discuss key open questions.