Highly Stretchable Metal-Polymer Conductor Electrode Array for Electrophysiology
Highly Stretchable Metal-Polymer Conductor Electrode Array for Electrophysiology
复制标题
用于电生理学的高可拉伸金属聚合物导体电极阵列
DOI：
10.1002/adhm.202000641
复制
发表时间：
2020-09-16
影响因子：
10
通讯作者：
Jiang, Xingyu
中科院分区：
文献类型：
--
作者：
Dong, Ruihua;Liu, Xiaoyan;Jiang, Xingyu
缩小生物组织（通常是软组织）和神经接口（硬组织）之间的机械失配对于维持神经活动电记录的信号质量至关重要。然而，只有少数材料可以满足此类电子产品的所有要求，这些电子产品需要既具有生物相容性又足够柔软。这里，引入了一种基于液态金属聚合物导体（MPC）的高度可拉伸电极阵列（SEA），为神经接口实现了高机械灵活性和良好的细胞相容性。通过利用 MPC，SEA 表现出高拉伸性（接近 100%）和出色的循环稳定性（>400 次循环）。 SEA 的细胞相容性可以实现原代神经元的长期培养，并能够记录原代海马神经元的信号。未来，SEA 可以作为神经组织诊断的可靠且强大的平台，并极大地推进脑机接口。
Narrowing the mechanical mismatch between biological tissues (typically soft) and neural interfaces (hard) is essential for maintaining signal quality for the electrical recording of neural activity. However, only a few materials can satisfy all requirements for such electronics, which need to be both biocompatible and sufficiently soft. Here, a highly stretchable electrode array (SEA) is introduced, based on the liquid metal-polymer conductor (MPC), achieving high mechanical flexibility and good cytocompatability for neural interfaces. By utilizing the MPC, the SEA exhibits high stretchability (approximate to 100%) and excellent cycling stability (>400 cycles). The cytocompatability of the SEA can allow for long-term culturing of primary neurons and enable signal recording of primary hippocampal neurons. In the future, the SEA could serve as a reliable and robust platform for diagnostics in neuronal tissues and greatly advance brain-machine interfaces.