Adenosine and stroke: maximizing the therapeutic potential of adenosine as a prophylactic and acute neuroprotectant.
Adenosine and stroke: maximizing the therapeutic potential of adenosine as a prophylactic and acute neuroprotectant.
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腺苷和中风：最大限度地发挥腺苷作为预防性和急性神经保护剂的治疗潜力。
DOI：
10.2174/157015909789152209
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发表时间：
2009-09
影响因子：
5.3
通讯作者：
Stenzel-Poore MP
中科院分区：
文献类型：
--
作者：
Williams-Karnesky RL;Stenzel-Poore MP
在美国，中风是发病率和死亡率的主要原因。尽管对减轻脑血管损伤严重程度的治疗方法的开发进行了密集的研究，但目前还没有主要的治疗方法。虽然腺苷在卒中中作为神经保护剂的潜在用途早已被认识到，但目前还没有基于腺苷的治疗脑缺血和再灌注的方法。开发以腺苷为基础的治疗中风的方法的主要障碍之一是中枢神经系统外功能性腺苷受体的普遍存在。外周免疫和血管内皮细胞的活动特别容易受到腺苷受体的调节。中风的许多病理生理过程是外周免疫渗入大脑的直接结果。缺血预适应可由多种刺激诱导，已成为卒中治疗发展的一个有前途的研究领域。大脑的重新编程和对腺苷信号的免疫反应可能是对脑缺血耐受的基本原则。深入了解腺苷在各种预适应范例中的作用，可能会导致腺苷作为一种急性和预防性神经保护剂的新用途。
Stroke is a leading cause of morbidity and mortality in the United States. Despite intensive research into the development of treatments that lessen the severity of cerebrovascular injury, no major therapies exist. Though the potential use of adenosine as a neuroprotective agent in the context of stroke has long been realized, there are currently no adenosine-based therapies for the treatment of cerebral ischemia and reperfusion. One of the major obstacles to developing adenosine-based therapies for the treatment of stroke is the prevalence of functional adenosine receptors outside the central nervous system. The activities of peripheral immune and vascular endothelial cells are particularly vulnerable to modulation via adenosine receptors. Many of the pathophysiological processes in stroke are a direct result of peripheral immune infiltration into the brain. Ischemic preconditioning, which can be induced by a number of stimuli, has emerged as a promising area of focus in the development of stroke therapeutics. Reprogramming of the brain and immune responses to adenosine signaling may be an underlying principle of tolerance to cerebral ischemia. Insight into the role of adenosine in various preconditioning paradigms may lead to new uses for adenosine as both an acute and prophylactic neuroprotectant.
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