Functional characterisation of autoantibodies from patients with pediatric opsoclonus-myoclonus-syndrome
Functional characterisation of autoantibodies from patients with pediatric opsoclonus-myoclonus-syndrome
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DOI：
10.1016/j.jneuroim.2005.08.018
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发表时间：
2005-12-30
影响因子：
3.3
通讯作者：
Blaes, F
中科院分区：
文献类型：
--
作者：
Korfei, M;Fühlhuber, V;Blaes, F
儿童和成人的副视阵挛肌阵挛综合征 (OMS) 被怀疑是针对肿瘤和神经元细胞交叉反应蛋白的自身免疫反应的结果。我们在这里表征了来自 11 名患有和不患有神经母细胞瘤的 OMS 儿童的 IgG 级分中的抗神经母细胞瘤抗体的结合和功能活性，来自不患有 OMS (NB) 的神经母细胞瘤的 IgG 级分和健康儿童作为对照。间接免疫荧光和蛋白质印迹显示所有 OMS 患者中 IgG 与细胞内自身抗原结合，但只有一名对照患者 (p
Parancoplastic opsoclonus-myoclonus-syndrome (OMS) both in children and adults is suspected to be the result of an autoimmune response directed against cross-reactive proteins of tumor and neuronal cells. We here characterised the binding and functional activities of anti-neuroblastoma antibodies in IgG fractions from 11 OMS children with and without neuroblastoma, IgG fractions from neuroblastoma without OMS (NB) and healthy children served as controls. Indirect immunoflorescence and Western blot revealed IgG binding to intracellular autoantigens in all OMS patients, but in only one of the controls (p