Leukoencephalopathy in normal and pathologic aging: 2. MRI of brain lucencies.
Leukoencephalopathy in normal and pathologic aging: 2. MRI of brain lucencies.
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正常和病理衰老中的白质脑病：2. 脑透亮区的 MRI。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
N. Chase
中科院分区：
文献类型：
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作者：
A. George;M. Leon;A. Kalni;Lisa Rosne;Albert Goodgold;N. Chase
进行了一项试点研究，以测试 MR 评估阿尔茨海默病患者和正常对照受试者 CT 显示的大脑透明度的能力。研究人员对 8 名疑似患有阿尔茨海默病的患者和 47 名正常对照进行了研究，其中 12 名年龄在 45 岁以上，35 名年龄在 45 岁以下。每组均包括有或没有 CT 证据显示白质脑病的受试者。使用 0.3-T 永磁体原型单元获得反转恢复、饱和恢复和自旋回波扫描。结果表明，MR 对实质疾病比 CT 更敏感。八名阿尔茨海默病患者中的七名在 SE 扫描中显示出信号强度增加的斑块；只有三人的 CT 研究具有透明度。 45 岁以下的正常受试者均未出现脑室周围 SE 信号强度增加的斑块。对 12 名 45 岁以上正常受试者中的 9 名进行了 T2 加权 SE 成像。九个中的八个显示脑室周围斑块的 SE 信号强度增加。其中仅一处出现微弱的 CT 透亮。正常组和阿尔茨海默病组的信号强度增加斑块的结构相似，但阿尔茨海默病组白质受累的程度更大。
A pilot study was performed to test the ability of MR to evaluate the brain lucencies shown by CT in Alzheimer disease patients and in normal control subjects. Eight patients with presumed Alzheimer disease and 47 normal controls, 12 over the age of 45 years and 35 under age 45, were studied. Each group included subjects with and without CT evidence of leukoencephalopathy. Inversion recovery, saturation recovery, and spin-echo scans were obtained using a 0.3-T permanent magnet prototype unit. Results indicated that MR was more sensitive than CT to parenchymal disease. Seven of the eight patients with Alzheimer disease showed patches of increased signal intensity on SE scans; only three had lucencies on their CT studies. None of the normal subjects under the age of 45 showed periventricular patches of increased SE signal intensity. T2-weighted SE imaging was performed in nine of the 12 normal subjects over 45 years old. Eight of the nine demonstrated periventricular patches of increased SE signal intensity. Faint CT lucencies were present in only one of these. The configuration of the patches of increased signal intensity was similar for both the normal and Alzheimer groups, but the extent of white-matter involvement was greater in the Alzheimer group.