Development of novel alginate based hydrogel films for wound healing applications
Development of novel alginate based hydrogel films for wound healing applications
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DOI：
10.1016/j.ijbiomac.2012.09.031
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发表时间：
2013-01-01
影响因子：
8.2
通讯作者：
Bartolo, Paulo
中科院分区：
文献类型：
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作者：
Pereira, Ruben;Carvalho, Anabela;Bartolo, Paulo
海藻酸盐和芦荟是生物医学领域广泛研究和使用的天然材料。在这项研究工作中，制备并表征了由不同比例（95:5、85:15 和 75:25，v/v）的海藻酸盐和芦荟凝胶组成的水凝胶薄膜。对薄膜的光传输行为、接触角测量以及化学、热和机械性能进行了评估。这些水凝胶薄膜是使用 5% 氯化钙溶液通过交联反应制备的，还对其水溶性和溶胀行为进行了研究。结果表明，芦荟提高了薄膜的透明度及其热稳定性。开发的薄膜具有适合皮肤应用的足够的机械性能，而溶解度研究表明薄膜在蒸馏水中浸泡 24 小时后不溶解。通过芦荟比例的增加，这些薄膜的吸水和溶胀行为得到了极大的改善。 (c) 2012 Elsevier B.V. 保留所有权利。
Alginate and Aloe vera are natural materials widely investigated and used in the biomedical field. In this research work, thin hydrogel films composed by alginate and Aloe vera gel in different proportions (95:5, 85:15 and 75:25, v/v) were prepared and characterized. The films were evaluated regarding the light transmission behavior, contact angle measurements, and chemical, thermal and mechanical properties. These thin hydrogel films, prepared by crosslinking reaction using 5% calcium chloride solution, were also investigated relatively to their water solubility and swelling behavior. Results showed that Aloe vera improved the transparency of the films, as well their thermal stability. The developed films present adequate mechanical properties for skin applications, while the solubility studies demonstrated the insolubility of the films after 24 h of immersion in distilled water. The water absorption and swelling behavior of these films were greatly improved by the increase in Aloe vera proportion. (c) 2012 Elsevier B.V. All rights reserved.