Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye
Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye
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DOI：
10.1016/j.ydbio.2008.05.528
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发表时间：
2008-08-01
影响因子：
2.7
通讯作者：
Wallace, Valerie A.
中科院分区：
文献类型：
--
作者：
Dakubo, Gabriel D.;Mazerolle, Chantal;Wallace, Valerie A.
眼外眼眶结构的发育，特别是脉络膜和巩膜，受到神经外胚层、神经脊和中胚层衍生物之间一系列复杂的相互作用的调节，尽管在许多情况下，调节这些相互作用的信号尚不清楚。在这项研究中，我们研究了印度刺猬(IHH)在哺乳动物眼睛发育中的作用。我们发现IHH在位于RPE附近发育中的脉络膜的一群无色素细胞中表达。对HH突变小鼠的分析表明，RPE和发育中的巩膜间充质是LHH信号的直接靶点，而IHH是RPE正常着色模式和间充质细胞凝聚形成巩膜所必需的。我们的发现还表明，IHH间接地发出信号，促进神经视网膜中的增殖和光感受器规范。这项研究确认LHH是一种新的脉络膜信号，调节RPE、巩膜和神经视网膜的发育。(C)2008 Elsevier Inc.保留所有权利。
The development of extraocular orbital structures, in particular the choroid and sclera, is regulated by a complex series of interactions between neuroectoderm, neural crest and mesoderm derivatives, although in many instances the signals that mediate these interactions are not known. In this study we have investigated the function of Indian hedgehog (Ihh) in the developing mammalian eye. We show that Ihh is expressed in a population of non-pigmented cells located in the developing choroid adjacent to the RPE. The analysis of Hh mutant mice demonstrates that the RPE and developing scleral mesenchyme are direct targets of lhh signaling and that Ihh is required for the normal pigmentation pattern of the RPE and the condensation of mesenchymal cells to form the sclera. Our findings also indicate that Ihh signals indirectly to promote proliferation and photoreceptor specification in the neural retina. This study identifies lhh as a novel choroid-derived signal that regulates RPE, sclera and neural retina development. (C) 2008 Elsevier Inc. All rights reserved.