Possible ancestral structure in human populations.
Possible ancestral structure in human populations.
复制标题
人口中可能的祖先结构。
DOI：
10.1371/journal.pgen.0020105
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发表时间：
2006-07
期刊：
影响因子：
4.5
通讯作者：
Wall, Jeffrey D.
中科院分区：
文献类型：
--
作者：
Plagnol, Vincent;Wall, Jeffrey D.
确定尼安德特人等古人类化石群体与现代人类之间的进化关系，一直是人类进化遗传学中一个备受关注的问题。在此我们提出一种新方法，利用当代人类群体的变异模式来解决古代人类群体是否对现代基因库有贡献（称为古代混血）这一问题。我们的方法在进行分析之前明确考虑了近期的种群历史，从而改进了先前的研究。利用环境基因组计划的序列数据，我们在欧洲和西非的一个种群中都发现了古代混血的有力证据（p≈10⁻⁷），对现代基因库的贡献至少为5%。虽然尼安德特人在欧洲是一个明显的古代源种群候选者，但在西非还没有一个明确的源种群候选者。
确定现代人类与尼安德特人等古人类群体之间的进化关系，一直是人类进化遗传学中一个备受关注的问题。在本文中，普拉尼奥尔（Plagnol）和沃尔（Wall）提出了一种新方法来解决古代人类群体是否对现代基因库有贡献的问题。利用环境基因组计划的序列数据，他们在欧洲和西非的一个种群中都发现了古代混血的有力证据，对现代基因库的贡献至少为5%。虽然尼安德特人在欧洲是一个明显的古代源种群候选者，但在西非还没有一个明确的源种群候选者。作者的研究结果对现代人类起源的相互竞争的模型有直接影响。特别是，他们对古代种群对现代基因库有不可忽视的贡献的估计，与严格的“近期非洲起源”模型不一致，该模型假定现代人类在非洲的一个单一地点进化，然后从那里扩散并取代了所有其他现存的古人类。
Determining the evolutionary relationships between fossil hominid groups such as Neanderthals and modern humans has been a question of enduring interest in human evolutionary genetics. Here we present a new method for addressing whether archaic human groups contributed to the modern gene pool (called ancient admixture), using the patterns of variation in contemporary human populations. Our method improves on previous work by explicitly accounting for recent population history before performing the analyses. Using sequence data from the Environmental Genome Project, we find strong evidence for ancient admixture in both a European and a West African population (p ≈ 10−7), with contributions to the modern gene pool of at least 5%. While Neanderthals form an obvious archaic source population candidate in Europe, there is not yet a clear source population candidate in West Africa. Determining the evolutionary relationships between modern humans and fossil hominine groups such as Neanderthals has been a question of enduring interest in human evolutionary genetics. In this paper, Plagnol and Wall present a new method for addressing whether archaic human groups contributed to the modern gene pool. Using sequence data from the Environmental Genome Project, they find strong evidence for ancient admixture in both a European and a West African population, with contributions to the modern gene pool of at least 5%. While Neanderthals form an obvious archaic source population candidate in Europe, there is not yet a clear source population candidate in West Africa. The authors' results have direct implications for the competing models of modern human origins. In particular, their estimates of non-negligible contributions of archaic populations to the modern gene pool are inconsistent with strict forms of the Recent African Origin model, which posits that modern humans evolved in a single location in Africa and from there spread and replaced all other existing hominines.
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