Differential oscillatory properties of cholinergic and noncholinergic nucleus basalis neurons in guinea pig brain slice
Differential oscillatory properties of cholinergic and noncholinergic nucleus basalis neurons in guinea pig brain slice
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DOI：
10.1111/j.1460-9568.1996.tb01178.x
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发表时间：
1996-01-01
影响因子：
3.4
通讯作者：
Muhlethaler, M
中科院分区：
文献类型：
--
作者：
Alonso, A;Khateb, A;Muhlethaler, M
有证据表明，大细胞基底核具有影响大脑皮质功能状态的潜力，通过该核中胆碱能细胞的地形组织和广泛的投射。研究还表明，除了胆碱能神经元外，其他非胆碱能的大细胞基底前脑神经元，其中一些已被鉴定为γ -氨基丁酸能神经元，投射到大脑皮层，因此也可能参与其活动的调节。我们通过豚鼠脑切片的细胞内记录，对基底核胆碱乙酰转移酶（ChAT）阳性和阴性细胞的免疫组织化学和形态学特征进行了比较研究。我们的研究结果表明，相对较大的多极胆碱能神经元和非胆碱能神经元各自表现出不同的电压依赖特性，使它们能够在低频下分别以尖峰爆发和尖峰簇有节奏地放电(
Evidence has suggested that the nucleus basalis magnocellularis has the potential to influence the functional state of the cerebral cortex through topographically organized, widespread projections of the cholinergic cells in that nucleus. It has also been shown that, in addition to the cholinergic neurons, other non-cholinergic magnocellular basal forebrain neurons, some of which have been identified as gamma-aminobutyric acid-ergic, project into the cerebral cortex and thus may also participate in the modulation of its activity. We have performed a comparative study of the intrinsic rhythmic properties of immunohistochemically and morphologically characterized choline acetyltransferase (ChAT)-positive and ChAT-negative cells of the nucleus basalis by means of intracellular recordings in guinea pig brain slices. Our results demonstrate that relatively large, multipolar cholinergic and non-cholinergic neurons each display differential voltage-dependent properties that allow them to discharge rhythmically in spike bursts and spike clusters, respectively, at low frequencies (