Temporally regulated expression of insulin and insulin‐like growth factors and their receptors in early mammalian development
Temporally regulated expression of insulin and insulin‐like growth factors and their receptors in early mammalian development
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DOI：
10.1002/bies.950110604
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发表时间：
1989-12
期刊：
影响因子：
4
通讯作者：
S. Heyner;Robert M. Smith;G. Schultz
中科院分区：
文献类型：
--
作者：
S. Heyner;Robert M. Smith;G. Schultz
近年来对脊椎动物和脊椎动物早期发育的研究表明，生长因子及其受体在细胞分化和增殖中起重要作用。在小鼠胚胎中，胰岛素和胰岛素样生长因子I和II（IGF-I和IGF-II）受体的表达受到时间调节。胰岛素和IGF基因家族内受体和配体表达的个体发生表明，哺乳动物胚胎发生的最早阶段可能受到来自母体和胚胎来源的自分泌和旁分泌因子的调节。
Recent studies of early development in a number of ivertebrate and vertebrate species have suggested that growth factors and their receptors may play important roles in differentiation as well as cell proliferation. In the mouse embryo, the expression of the receptors for insulin and insulin‐like growth factors I and II (IGF‐I and ‐II) are temporally regulated. The ontogeny of receptor and ligand expression within the insulin and IGF gene family suggests that the very earliest stages of mammalian embryogenesis may be subject to regulation by autocrine and paracrine factors from maternal and embryonic sources.