A functional single‐nucleotide polymorphism in the ERCC1 gene alters the efficacy of narrowband ultraviolet B therapy in patients with active vitiligo in a Chinese population
A functional single‐nucleotide polymorphism in the ERCC1 gene alters the efficacy of narrowband ultraviolet B therapy in patients with active vitiligo in a Chinese population
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DOI：
10.1111/bjd.13892
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发表时间：
2015-08
影响因子：
10.3
通讯作者：
W. Dai;Fubo Zhou;Chao Wei;Xiaowen Wang;Shuzhong Guo;X. Yi;Kai Li;Tianwen Gao;Ling Liu;C. Li
中科院分区：
文献类型：
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作者：
W. Dai;Fubo Zhou;Chao Wei;Xiaowen Wang;Shuzhong Guo;X. Yi;Kai Li;Tianwen Gao;Ling Liu;C. Li
在白癜风的发病机制中，T淋巴细胞可导致黑素细胞的破坏。窄带中波紫外线(NB-UVB)作为治疗白癜风的有效手段，可导致皮损周围淋巴细胞产生环丁烷嘧啶二聚体(CPDS)等DNA光产物，从而引起皮肤免疫抑制。DNA光产物的修复主要通过核苷酸切除修复(NER)途径进行。我们假设NER基因中的单核苷酸多态(SNPs)可能影响CPD的修复能力，从而导致光疗效率的变化。
T lymphocytes have been shown to cause the destruction of melanocytes in vitiligo pathogenesis. Narrowband ultraviolet B (NB‐UVB), as an effective therapeutic strategy in vitiligo, can lead to the formation of DNA photoproducts such as cyclobutane pyrimidine dimers (CPDs) in perilesional lymphocytes and thus induce skin immunosuppression. The repair of DNA photoproducts is performed mainly through the nucleotide excision repair (NER) pathway. We hypothesized that single‐nucleotide polymorphisms (SNPs) in NER genes might influence the repair capacity of CPDs and thus contribute to variations in phototherapy efficiency.