T cell immunity to measles viral proteins in infants and adults after measles immunization
T cell immunity to measles viral proteins in infants and adults after measles immunization
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DOI：
10.1089/0882824041310522
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发表时间：
2004-06-01
期刊：
影响因子：
2.2
通讯作者：
Arvin, AM
中科院分区：
文献类型：
--
作者：
Gans, HA;Yasukawa, LL;Arvin, AM
为婴儿接种麻疹疫苗仍然具有全球重要性，提出的新疫苗战略包括使用麻疹蛋白或合成肽作为免疫原。我们研究了免疫成人和婴儿接种麻疹疫苗后对麻疹全抗原和麻疹蛋白的细胞介导免疫。此外，我们测量了接种麻疹疫苗的成人中CD 8（+）T细胞对对应于核衣壳（N）麻疹蛋白的肽库的应答。在免疫成人中，对四种麻疹蛋白中的三种的细胞介导的免疫应答相当于对整个麻疹抗原的免疫应答。与完整麻疹抗原相比，婴儿对融合（F）蛋白的反应较低（p <0.03）。婴儿对麻疹全抗原和F蛋白的反应均低于成人（P小于或等于0.001）。麻疹疫苗接种后，CD 8（+）T细胞对N肽池的反应各不相同，免疫HLA-A2阳性个体与幼稚和HLA-A2阴性个体之间存在差异。与成人相比，婴儿的麻疹特异性T细胞适应性反应有限，包括对F蛋白的反应。
Vaccination of infants against measles remains of global importance, and proposed new vaccine strategies include the use of measles proteins or synthetic peptides as immunogens. We studied cell-mediated immunity to whole measles antigen and measles proteins in immune adults and infants after measles vaccine. Further, we measured CD8(+) T cell responses to peptide pools corresponding to the nucelocapsid (N) measles protein in adults given measles vaccine. Cell-mediated immune responses to three of four measles proteins were equivalent to those against whole measles antigen in immune adults. Responses to the fusion (F) protein were lower in infants compared to whole measles antigen (p less than or equal to 0.03). Infant responses to both whole measles antigen and the F protein were lower compared with these responses in adults (P less than or equal to 0.001). CD8(+) T cell responses to N peptide pools varied, and differed between immune HLA-A2-positive individuals compared with naive and HLA-A2-negative subjects after measles vaccination. The measles-specific T cell adaptive response of infants is limited compared to adults, including responses to the F protein.