High endothelial venules in involved and uninvolved psoriatic skin: recognition by homing receptors on cytotoxic T lymphocytes
High endothelial venules in involved and uninvolved psoriatic skin: recognition by homing receptors on cytotoxic T lymphocytes
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受累和未受累银屑病皮肤中的高内皮小静脉：细胞毒性 T 淋巴细胞上归巢受体的识别
DOI：
10.1111/j.1365-2133.1988.tb02423.x
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发表时间：
1988
影响因子：
10.3
通讯作者：
D. Chase
中科院分区：
文献类型：
--
作者：
M. Heng;S. Allen;D. Chase
我们报告的存在下，鞣酸染色材料在相邻的内皮细胞之间的间隙的高内皮小静脉（HEV）在银屑病皮肤，这似乎是公认的T8（细胞毒性/抑制）淋巴细胞，因为HEV的存在被发现是与表皮中的T8淋巴细胞的存在。由于在外周淋巴结中也观察到具有类似鞣酸染色材料的HEV，因此我们认为该材料可作为T8淋巴细胞亚群识别HEV的标记物。T8 +淋巴细胞在活动期银屑病患者的未受累皮肤胶带剥离后5 min和1 h在表皮中发现，但在缓解期银屑病患者中直到24 h才发现。先前在未受累的银屑病皮肤中存在的HEV可以解释T8淋巴细胞在创伤后从脉管系统快速流出到表皮的原因。
We report the presence of tannic acid staining material in the intercellular spaces between adjacent endothelial cells of the high endothelial venules (HEVs) in psoriatic skin, which appears to be recognized by T8 (cytotoxic/suppressor) lymphocytes, as the presence of HEVs was found to be related to the presence of T8 lymphocytes in the epidermis. As HEVs with similar tannic acid staining material were also observed in peripheral lymph nodes, we suggest that this material may serve as a marker for HEVs recognized by the T8 lymphocyte subset. T8 + lymphocytes were found in the epidermis at 5 min and 1 h after tape‐stripping of uninvolved skin of psoriatic patients with active disease, but not until 24 h in a psoriatic patient in remission. The prior existence of HEVs in uninvolved psoriatic skin could account for the rapid egress of T8 lymphocytes from the vasculature to the epidermis in response to trauma.