Evaluation of a Spiral Groove Geometry for Improvement of Hemolysis Level in a Hydrodynamically Levitated Centrifugal Blood Pump
Evaluation of a Spiral Groove Geometry for Improvement of Hemolysis Level in a Hydrodynamically Levitated Centrifugal Blood Pump
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DOI：
10.1111/aor.12546
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发表时间：
2015-08-01
影响因子：
2.4
通讯作者：
Maruyama, Osamu
中科院分区：
文献类型：
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作者：
Murashige, Tomotaka;Kosaka, Ryo;Maruyama, Osamu
本研究的目的是评估螺旋槽几何形状的推力轴承，以改善溶血水平的流体动力悬浮离心血泵。我们比较了三种几何模型：（i）在任何给定的极坐标下，凹槽宽度与脊宽度相同（常规模型）;（ii）凹槽宽度从9.7 mm向内收缩至0.5 mm（收缩模型）;以及（iii）凹槽宽度从0.5 mm向内扩展至4.2 mm（扩展模型）。为了评价溶血水平，使用模拟循环回路进行了叶轮悬浮性能试验和体外溶血试验。在这些测试中，驱动条件被设置为200 mmHg的压头和4.0 L/min的流速。作为叶轮悬浮性能测试的结果，收缩和常规模型的底部轴承间隙分别为88和25 m。膨胀模型的叶轮接触底部外壳。在溶血试验中，与BPX-80和HPM-15相比，收缩模型的相对标准化溶血指数（NIH）比率分别为0.6和0.9。相反，与BPX-80和HPM-15相比，常规模型的相对NIH比率分别为9.6和13.7。我们证实，收缩模型实现了一个大的轴承间隙，并改善了溶血水平的流体动力悬浮离心血泵。
The purpose of this study is to evaluate a spiral groove geometry for a thrust bearing to improve the hemolysis level in a hydrodynamically levitated centrifugal blood pump. We compared three geometric models: (i) the groove width is the same as the ridge width at any given polar coordinate (conventional model); (ii) the groove width contracts inward from 9.7 to 0.5mm (contraction model); and (iii) the groove width expands inward from 0.5 to 4.2mm (expansion model). To evaluate the hemolysis level, an impeller levitation performance test and in vitro hemolysis test were conducted using a mock circulation loop. In these tests, the driving conditions were set at a pressure head of 200mmHg and a flow rate of 4.0L/min. As a result of the impeller levitation performance test, the bottom bearing gaps of the contraction and conventional models were 88 and 25m, respectively. The impeller of the expansion model touched the bottom housing. In the hemolysis test, the relative normalized index of hemolysis (NIH) ratios of the contraction model in comparison with BPX-80 and HPM-15 were 0.6 and 0.9, respectively. In contrast, the relative NIH ratios of the conventional model in comparison with BPX-80 and HPM-15 were 9.6 and 13.7, respectively. We confirmed that the contraction model achieved a large bearing gap and improved the hemolysis level in a hydrodynamically levitated centrifugal blood pump.