PET and MR studies of experimental focal stroke.
PET and MR studies of experimental focal stroke.
复制标题
实验性局灶性中风的 PET 和 MR 研究。
DOI：
10.1097/00004728-199105000-00006
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发表时间：
1991
影响因子：
1.3
通讯作者：
Brownell,GL
中科院分区：
文献类型：
--
作者：
Brownell,AL;Kano,M;McKinstry,RC;Moskowitz,MA;Rosen,BR;Brownell,GL
正电子发射断层扫描（PET）和MR与组织化学病理学进行了比较，以显示大鼠大脑中动脉（MCA）闭塞后，结合暂时性双侧颈总动脉闭塞在Long Evans大鼠的大脑中受影响的组织区域。对应于大脑中动脉闭塞区域的右侧皮质灰质的葡萄糖代谢率为65+/-8 [mu] mol/100 ml/min，对应于（左侧）正常侧的葡萄糖代谢率为93+/-8 [mu] mol/100 ml/min。在MCA闭塞同侧的MR T2加权扫描中，闭塞组织显示PET活性降低和信号增加。这些区域对应于用3-4-5氯化三苯基四氮唑染色的冠状组织切片中鉴定的局灶性梗死区。本研究表明，PET可用于研究葡萄糖利用在大鼠中风模型在体内和无创。
Positron emission tomography (PET) and MR have been compared with histochemical pathology to show affected tissue areas in rat brain after right middle cerebral artery (MCA) occlusion combined with temporary bilateral common carotid artery occlusion in Long Evans rats. The glucose metabolic rate was 65+/-8 [mu] mol/100 ml/min in the right cortical gray matter corresponding to the occluded middle cerebral artery territory and 93+/-8 ([mu] mol/100 ml/min in the corresponding (left) normal side. Infarcted tissue showed decreased PET activity and increased signal in MR T2-weighted scans ipsilateral to the MCA occlusion. These regions correspond to a zone of focal infarction identified in coronal tissue sections stained with 3-4-5 triphenyl tetrazolium chloride. This study demonstrates that PET can be used to study glucose utilization in rat stroke model in vivo and noninvasively.