Further evidence for individual differences in placebo responding: An interactionist perspective
Further evidence for individual differences in placebo responding: An interactionist perspective
复制标题
DOI：
10.1016/j.jpsychores.2006.12.005
复制
发表时间：
2007-05-01
影响因子：
4.7
通讯作者：
Wellman, Justin A.
中科院分区：
文献类型：
--
作者：
Geers, Andrew L.;Kosbab, Kristin;Wellman, Justin A.
目的：一项先前的调查发现，乐观情绪低的人更有可能遵循消极的安慰剂（nocebo）预期。本研究验证了一个假设，即乐观的人更有可能遵循积极的安慰剂期望。方法：个人（N = 56）在他们的乐观程度不同，被随机分配到三个条件之一。在第一种情况下，参与者被给予安慰剂睡眠治疗将改善他们的睡眠质量的期望（安慰剂期望条件）。在第二种情况下，参与者从事相同的睡眠治疗活动，但没有给予积极的安慰剂期望（治疗对照条件）。最后，第三组没有接受积极的安慰剂期望，也没有进行安慰剂睡眠治疗（无安慰剂对照条件）。结果：在安慰剂预期条件下，乐观与更好的睡眠质量呈正相关（r = 0.48，P <0.05）。在治疗对照组（r =-0.17，P = 0.46）和无安慰剂对照组（r =-0.24，P = 35）中，乐观得分与更好的睡眠质量无关。结论：性格乐观与安慰剂反应有关。然而，这种关系并不表现在所有类型的安慰剂反应的简单增加或减少。相反，随着乐观情绪的增加，对积极安慰剂期望的反应似乎会增加，而对反安慰剂期望的反应则会减少。建议未来人格和安慰剂效应的研究应考虑情境变量和倾向变量之间的相互作用。(C)2007爱思唯尔公司All rights reserved.
Objective: A prior investigation found that individuals low in optimism are more likely to follow a negative placebo (nocebo) expectation. The present study tested the hypothesis that individuals high in optimism are more likely to follow a positive placebo expectation. Methods: Individuals (N = 56) varying in their level of optimism were randomly assigned to one of three conditions. In the first condition, participants were given the expectation that a placebo sleep treatment would improve their sleep quality (placebo expectation condition). In the second condition, participants engaged in the same sleep treatment activity but were not given the positive placebo expectation (treatment control condition). Finally, a third group did not receive the positive placebo expectation and also did not engage in the placebo sleep treatment (no-placebo control condition). Results: Optimism was positively associated with better sleep quality in the placebo expectation condition (r = .48, P < .05). Optimism scores were not associated with better sleep quality in either the treatment control condition (r = -.17, P = .46) or the no-placebo control condition (r = -.24, P = 35). Conclusion: Dispositional optimism relates to placebo responding. This relationship, however, is not manifested in a simple increase or decrease in all types of placebo responding. Rather, it appears that, as optimism increases, response to the positive placebo expectation increases, whereas response to nocebo expectation decreases. It is recommended that future research on personality and placebo effects consider the interaction between situational and dispositional variables. (C) 2007 Elsevier Inc. All rights reserved.