Porous titanium-nickel for intervertebral fusion in a sheep model: Part 1. Histomorphometric and radiological analysis
Porous titanium-nickel for intervertebral fusion in a sheep model: Part 1. Histomorphometric and radiological analysis
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DOI：
10.1002/jbm.b.10530
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发表时间：
2003-02-15
影响因子：
3.4
通讯作者：
Rivard, CH
中科院分区：
文献类型：
--
作者：
Assad, M;Jarzem, P;Rivard, CH
多孔钛镍（PTN）植入物是传统椎间融合器的替代品。事实上，PTN 材料具有具有细胞毛细管特性的互连孔，可以促进骨向内生长和椎间融合，而无需骨移植。在这项研究中，在绵羊模型中将 PTN 椎间融合装置与填充自体骨的传统 TiAlV 融合器进行了比较。这两个装置分别植入两个不连续的椎间腰椎部位，分别植入 3、6 和 12 个月。 PTN 骨整合显示出随时间增加的趋势，从 21.4% 增加到 37.6%（3-12 个月），而 TiAlV 保持架保持相同的骨向内生长水平（22.7%-25.4%；3-12 个月）。此外，PTN 骨沉积（10.9%-24.2%；3-12 个月）显着高于 TiAlV 种植体（1.1%-5.1%；3-12 个月；p < 0.001，方差分析）。无论材料类型如何，放射学融合评分都会随着术后时间的推移而增加，但 PTN（12.5-18.5；3-12 个月）始终优于 TiAlV 笼（2.0-15.0；3-12 个月；p < 0.001，方差分析）。根据基于术前椎间盘高度的放射学椎间指数，植入材料没有显着差异：手术后椎间指数开始为 132.6% (PTN) 和 123.5% (TiAlV)，然后在 12 个月后下降至 80.8% (PTN) 和 91.0% (TiAlV)。尽管如此，未移植的 PTN 构成了成骨细胞整合的优异基质，并且代表了一种新型骨传导生物材料，与传统的 TiAlV 融合器相比，具有改进的融合特性。 (C) 2003 年 Wiley 期刊公司。
Porous titanium-nickel (PTN) implants represent an alternative to traditional intervertebral fusion cages. Indeed, PTN materials possess interconnecting pores with cell capillarity properties that may promote bone ingrowth and intervertebral fusion without the need for bone grafting. In this study, a PTN intervertebral fusion device was compared to a conventional TiAlV cage packed with autologous bone in a sheep model. The two devices were implanted at two noncontiguous intervertebral lumbar sites for 3, 6, and 12 months. PTN osseointegration showed a time-dependent trend increasing from 21.4% to 37.6% (3-12 months), whereas TiAlV cages remained at the same level of bone ingrowth (22.7%-25.4%; 3-12 months). Furthermore, PTN bone apposition (10.9%-24.2%; 3-12 months) was significantly higher than that of TiAlV implants (1.1%-5.1%; 3-12 months; p < 0.001, ANOVA). Radiological fusion scores increased with postsurgery time regardless of material type, but were consistently superior for PTN (12.5-18.5; 3-12 months) than for TiAlV cages (2.0-15.0; 3-12 months; p < 0.001, ANOVA). Implant materials were not significantly different according to the radiological interbody index based on preoperative disc height: Interbody index began at 132.6% (PTN) and 123.5% (TiAlV) immediately after surgery, then declined to 80.8% (PTN) and 91.0% (TiAlV) after 12 months. Nevertheless, ungrafted PTN constituted an excellent substrate for osteogenic cell integration and represents a new osteoconductive biomaterial with improved fusion characteristics in comparison to conventional TiAlV cages. (C) 2003 Wiley Periodicals, Inc.