Local aggregation of hormone–receptor complexes is required for activation by epidermal growth factor
Local aggregation of hormone–receptor complexes is required for activation by epidermal growth factor
复制标题
表皮生长因子的激活需要激素-受体复合物的局部聚集
DOI：
10.1038/278835a0
复制
发表时间：
1979
期刊：
影响因子：
64.8
通讯作者：
P. Cuatrecasas
中科院分区：
文献类型：
--
作者：
Yoram Schechter;L. Hernaez;J. Schlessinger;P. Cuatrecasas
表皮生长因子（EGF）的类似物实际上缺乏生物活性，保留了受体结合活性，但不能形成细胞表面簇或斑块。二价抗 EGF 抗体恢复生物活性和斑块形成。这些抗体也可以大大增强成纤维细胞对天然 EGF 的敏感性，尤其是在激素抗性细胞系中。
An analogue of epidermal growth factor (EGF) which is virtually devoid of biological activity retains receptor binding activity but cannot form cell surface clusters or patches. Bivalent anti-EGF antibodies restore both bioactivity and patch formation. The sensitivity of fibroblasts to native EGF can also be enhanced greatly by these antibodies, especially in hormone-resistant cell lines.