Dietary fiber and progression of atherosclerosis: the Los Angeles Atherosclerosis Study.
Dietary fiber and progression of atherosclerosis: the Los Angeles Atherosclerosis Study.
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DOI：
10.1093/ajcn/78.6.1085
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发表时间：
2003-12
期刊：
影响因子：
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通讯作者：
Huiyun Wu;K. Dwyer;Zhihong Fan;A. Shircore;Jingxu Fan;J. Dwyer
中科院分区：
文献类型：
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作者：
Huiyun Wu;K. Dwyer;Zhihong Fan;A. Shircore;Jingxu Fan;J. Dwyer
几项流行病学研究发现，膳食纤维摄入量与心血管疾病事件风险之间的保护关系较弱。然而，很少有研究涉及这种影响的可能机制。目的在本研究中，我们估计动脉粥样硬化的进展和选择性膳食纤维组分的摄入之间的关系。调解的关系，血脂也进行了调查。设计：年龄40-60岁的无心脏病患者被纳入队列（n = 573; 47%为女性）。在基线检查和2次随访检查（n = 500）时通过超声测量颈总动脉内膜-中层厚度（IMT），通过6次24小时回顾（3次基线检查和3次首次随访检查）评估饮食摄入量，并在基线和两次随访检查时分析血液样本。结果IMT进展与粘性纤维（P = 0.05）和果胶（P = 0.01）的摄入量呈显著负相关。测量误差的校正增加了这些估计影响的幅度。总胆固醇与高密度脂蛋白胆固醇的比值与总纤维（P = 0.01）、粘性纤维（P = 0.05）和果胶（P = 0.01）的摄入量呈负相关。通过调整血脂，IMT进展与粘性纤维和果胶摄入量之间的关联程度减弱。结论：粘性纤维的摄入，尤其是果胶，似乎可以防止IMT进展。血脂可能是膳食纤维摄入与IMT进展之间的一种中介。
BACKGROUND Several epidemiologic studies found weak protective relations between dietary fiber intake and the risk of cardiovascular disease events. However, few of the studies addressed possible mechanisms of the effect. OBJECTIVE In the present study, we estimated relations between the progression of atherosclerosis and the intake of selective dietary fiber fractions. Mediation of the relations by serum lipids was also investigated. DESIGN Participants who were free of heart disease and aged 40-60 y were recruited into the cohort (n = 573; 47% women). The intima-media thickness (IMT) of the common carotid arteries was measured ultrasonographically at the baseline examination and at 2 follow-up examinations (n = 500), dietary intakes were assessed with six 24-h recalls (3 at baseline and 3 at the first follow-up examination), and blood samples were analyzed at baseline and at both follow-up examinations. RESULTS A significant inverse association was observed between IMT progression and the intakes of viscous fiber (P = 0.05) and pectin (P = 0.01). Correction for measurement error increased the magnitude of these estimated effects. The ratio of total to HDL cholesterol was inversely related to the intakes of total fiber (P = 0.01), viscous fiber (P = 0.05), and pectin (P = 0.01). The magnitude of the association between IMT progression and the intakes of viscous fiber and pectin was attenuated by adjustment for serum lipids. CONCLUSIONS The intake of viscous fiber, especially pectin, appears to protect against IMT progression. Serum lipids may act as a mediator between dietary fiber intake and IMT progression.