IDENTIFICATION OF MONOCYTE CHEMOTACTIC ACTIVITY PRODUCED BY MALIGNANT-CELLS
IDENTIFICATION OF MONOCYTE CHEMOTACTIC ACTIVITY PRODUCED BY MALIGNANT-CELLS
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DOI：
10.1126/science.2781291
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发表时间：
1989-09-29
期刊：
影响因子：
56.9
通讯作者：
VALENTE, AJ
中科院分区：
文献类型：
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作者：
GRAVES, DT;JIANG, YL;VALENTE, AJ
人类恶性肿瘤细胞分泌吸引外周血单核细胞的低分子量蛋白质，可能是体内观察到的肿瘤相关巨噬细胞积聚的原因。培养的血管平滑肌细胞分泌类似的趋化蛋白。不同来源的肿瘤细胞产生的主要单核细胞趋化因子被证明与平滑肌细胞衍生的趋化因子有关。因此，不同的细胞类型产生单一类别的趋化蛋白，这表明单核细胞和巨噬细胞募集的共同机制。鉴于巨噬细胞影响肿瘤生长的潜力，这些结果是重要的。
Human malignant cells secrete low molecular size proteins that attract peripheral blood monocytes and may be responsible for the accumulation of tumor-associated macrophages observed in vivo. Similar chemotactic proteins are secreted by cultured vascular smooth muscle cells. The predominant monocyte chemoattractants produced by tumor cells of differing origin were demonstrated to be related to smooth muscle cell-derived chemotactic factor. Thus, a single class of chemotactic proteins is produced by different cell types, which suggests a common mechanism for the recruitment of monocytes and macrophages. These results are significant in view of the potential of macrophages to affect tumor growth.