Low Birth Weight as Cardiometabolic Risk in Japanese High School Girls
Low Birth Weight as Cardiometabolic Risk in Japanese High School Girls
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DOI：
10.1080/07315724.2012.10720007
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发表时间：
2012-02
影响因子：
3.5
通讯作者：
M. Mori;H. Mori;Y. Yamori;K. Tsuda
中科院分区：
文献类型：
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作者：
M. Mori;H. Mori;Y. Yamori;K. Tsuda
目的：研究日本健康高中女生的出生体重与代谢综合征（MS）危险因素之间的关系。研究方法：在获得知情同意后，我们于2007年和2008年对243名年龄为16.4 ± 1.4岁的健康日本高中女生进行了食品教育计划（FEP）的健康调查，并检查了人体测量值，包括腹围、收缩压和舒张压测量患者的血压（分别为SBP和DBP）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL）、胰岛素和血糖，以计算午餐后禁食3小时后的胰岛素抵抗。出生体重通过产妇记录本进行检查，饮食习惯通过问卷进行记录。采用单因素方差分析和Bonferroni检验分析MS危险因素的患病率，并采用相关分析分析其与出生体重的关系。结果如下：根据日本儿童和成人MS危险因素的标准，肥胖、高血压、血脂异常和高血糖的患病率分别为7.4%、9.1%、7.0%和16.0%，仅在1名肥胖女孩和2名其他风险（高SBP和TG）中检测到MS。在报告出生体重的180例受试者中，出生体重与SBP（p = 0.007）、DBP（p = 0.033）、TG（p = 0.009）、胰岛素水平（p = 0.047）、胰岛素抵抗（p= 0.050）和代谢危险因素数量（p = 0.022）呈显著负相关。出生体重低于2500 g的13名女孩（7.2%）的SBP（p = 0.037）、DBP（p = 0.032）、TG（p = 0.011）、胰岛素水平（p=0.037）和胰岛素抵抗（p = 0.043）显著高于出生体重等于或大于3400 g的31名女孩（17.2%）。总结：即使在健康的日本高中女生中，也可以检测到低出生体重与MS风险（例如SBP、DBP、TG、胰岛素水平和胰岛素抵抗）的显着相关性，这表明对低出生体重儿童进行随访和FEP的重要性。对于预防晚年的MS。
Objective: To examine the relationships between birth weight and metabolic syndrome (MS) risk factors in healthy Japanese high school girls. Methods: After obtaining informed consent, we carried out health surveys for the Food Educational Program (FEP) in 2007 and 2008 in 243 healthy Japanese high school girls aged 16.4 ± 1.4 years and examined anthropometric measurements, including abdominal circumference, systolic and diastolic blood pressures (SBP and DBP, respectively), triglycerides (TG), high-density lipoprotein cholesterol (HDL), insulin, and blood glucose to calculate insulin resistance after fasting for 3 hours after lunch. Birth weight was checked by maternity record book, and food customs were recorded using a questionnaire. We analyzed the prevalence of MS risk factors by Bonferroni test following 1-way analysis of variance and their relationships with birth weight by correlation analyses. Results: According to criteria for MS risk factors in Japanese children and adults, the prevalence of obesity, high blood pressure, dyslipidemia, and high blood glucose was 7.4%, 9.1%, 7.0%, and 16.0%, respectively, and MS was detected in only 1 girl who had obesity and 2 more risks (high SBP and TG). Among 180 subjects who reported their birth weights, birth weights were significantly inversely related with SBP (p = 0.007), DBP (p = 0.033), TG (p = 0.009), insulin level (p = 0.047), insulin resistance ( p= 0.050), and number of metabolic risk factors (p = 0.022). Thirteen girls (7.2%) whose birth weights were lower than 2500 g had significantly higher SBP (p = 0.037), DBP (p = 0.032), TG (p = 0.011), insulin level (p=0.037), and insulin resistance (p = 0.043), than 31 girls (17.2%) with birth weights equal to or more than 3400 g. Conclusion: The association of low birth weight could be detected to be significant with such risks of MS as SBP, DBP, TG, insulin level, and insulin resistance even in healthy Japanese high school girls, indicating the importance of follow-up and FEP for children with low birth weight for the prevention of MS in the later life.