Lipids in Health and Disease
Lipids in Health and Disease
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DOI：
10.1109/cgc.2012.90
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
Jing-lin Jiang;P. Nilsson‐Ehle;N. Xu
中科院分区：
文献类型：
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作者：
Jing-lin Jiang;P. Nilsson‐Ehle;N. Xu
Liver plays a key role in the metabolism of plasma apolipoproteins, endogenous lipids and lipoproteins. Hepatocellular carcinoma (HCC) is one of the most common fatal malignant tumors in China and in other Southeast Asian countries. This has been attributed to the high incidence of hepatitis B infection. Hepatitis B proteins, such as the hepatitis B X protein (HBx) that is large hepatitis B surface protein could regulate transcription of many candidate genes for liver carcinogenesis. It has known that patients who suffered from acute hepatitis B could have lipid disorders such as decreased plasma level of high-density lipoproteins (HDL). Furthermore, aberrations of lipid metabolism are often seen in the chronic hepatitis B infection. Plasma lipid profiles could be changed under HCC. In majority of the reports in HCC, plasma levels of triglycerides (TG), cholesterol, free fatty acids (FFA), HDL, low-density lipoproteins (LDL), lipoprotein (a) (Lp(a)), apolipoprotein AI (apoAI) and apoB were slight to significantly decreased, however, in some cases plasma levels of TG and Lp(a) might be increased. It has been suggested that analysis of plasma levels of lipids, lipoproteins and apolipoproteins in the patients suffered from HCC reflects on the hepatic cellular impairment status. Studies revealed that alterations seen in the plasma levels of lipids, lipoproteins and apolipoproteins reflecting patients' pathologic conditions. Decreased serum levels of cholesterol and apoAI may indicate a poor prognosis. Human leukaemic cells and certain tumor tissues have a higher receptor-mediated uptake of HDL and LDL than the corresponding normal cells or tissues. LDL and HDL have therefore been proposed as a carrier for the water-insoluble anti-cancer agents. Introduction Liver is one of the most important organs in energy metabolism. Most plasma apolipoproteins, endogenous lipids and lipoproteins are synthesized in the liver [1,2], which depends on the integrity of cellular functions of liver [2,3]. Under normal physiological conditions, liver ensures homeostasis of lipid and lipoprotein metabolism [4]. Hepatic cellular damage and HCC impairs these processes, leading to alterations in plasma lipid and lipoprotein patterns. Mortality due to liver cancer is the fifth common malignant tumor worldwide [5], and it is closely related to the infections of hepatitis B virus (HBV) [6-8] and hepatitis C virus (HCV) [9]. HBV proteins, such as the hepatitis B X protein (HBx) that is large hepatitis B surface protein could regulate transcription of many candidate genes for liver carcinogenesis [10,11]. As HBV and HCV infections are quite common in China and in other Southeast Asian countries [12-14], the mortality of HCC is 20,4/ Published: 03 March 2006 Lipids in Health and Disease2006, 5:4 doi:10.1186/1476-511X-5-4 Received: 02 December 2005 Accepted: 03 March 2006 This article is available from: http://www.lipidworld.com/content/5/1/4 © 2006Jiang et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
