A Note of Caution: Variable Cytokeratin Staining in Sentinel Node Metastases
A Note of Caution: Variable Cytokeratin Staining in Sentinel Node Metastases
复制标题
DOI：
10.1177/1066896915596811
复制
发表时间：
2015-10-01
影响因子：
1.2
通讯作者：
Darvishian, Farbod
中科院分区：
文献类型：
--
作者：
Zeng, Jennifer;Alexander, Melissa Ann;Darvishian, Farbod
前哨淋巴结活检是目前用于对乳腺癌患者进行分期的标准程序。评估前哨淋巴结的最佳组织学方法在各机构之间存在激烈争论，因此没有标准化。最佳的组织学分析是前哨节点的综合评价与成本效益之间的平衡。一种常用的方法是连续切片并用苏木精和伊红交替染色以及 AE1/AE3 细胞角蛋白免疫组织化学分析。我们报告了 2 例 AE1/AE3 呈阴性染色的转移性癌病例。这一观察结果凸显了这种评估乳腺癌前哨淋巴结活检的常用策略存在一个罕见但潜在的缺陷。
Sentinel lymph node biopsy is the current standard procedure used to stage patients with breast cancer. The best histological method in evaluating sentinel nodes is highly debated among institutions and is thus not standardized. The optimal histological analysis is a balance between comprehensive evaluation of the sentinel nodes and cost effectiveness. One commonly used approach is serial sectioning and alternately staining with hemotoxylin and eosin and AE1/AE3 cytokeratin immunohistochemistry analysis. We report 2 cases of metastatic carcinoma demonstrating negative staining for AE1/AE3. This observation highlights a rare but potential pitfall to this commonly used strategy in assessing sentinel lymph node biopsies in breast cancer.