Serine-arginine protein kinases: new players in neurodegenerative diseases?
Serine-arginine protein kinases: new players in neurodegenerative diseases?
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DOI：
10.1515/revneuro-2013-0014
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发表时间：
2013-08-01
影响因子：
4.1
通讯作者：
Ye, Keqiang
中科院分区：
文献类型：
--
作者：
Chan, Chi Bun;Ye, Keqiang
丝氨酸-精氨酸蛋白激酶(SRPKs)是一组识别和磷酸化具有丝氨酸-精氨酸二肽重复序列的蛋白质底物的丝氨酸激酶。它们主要通过磷酸化剪接因子，如ASF/SF2和SC35来调节前mRNA的剪接。然而，尽管SRPKs在神经元中有显著的表达，但其在神经系统中的功能尚不清楚。我们最近的研究表明，SRPK成员之一SRPK2参与了阿尔茨海默病的神经元存活、细胞周期进展和记忆决定。因此，SRPKs是一组未被识别的蛋白质，可能促进神经变性引起的疾病的病理进展。在这篇综述中，我们将更新我们对SRPKs在各种细胞活动中的功能的认识，并讨论它们在神经退行性疾病中的潜在作用。
Serine-arginine protein kinases (SRPKs) are a group of serine kinases that recognize and phosphorylate protein substrates with serine-arginine dipeptide repeats. They are mainly involved in regulating pre-mRNA splicing via phosphorylating splicing factors, such as ASF/SF2 and SC35. Nevertheless, the functions of SRPKs in the nervous system are sketchy, although the kinases have significant expression in neurons. Our recent studies demonstrate that one of the SRPK members, SRPK2, participates in the neuronal survival, cell cycle progression, and memory determination in Alzheimer's disease. SRPKs are thus a group of unrecognized proteins that may facilitate the pathological progression of disorders caused by neurodegeneration. In this review, we will update our knowledge on SRPKs' functions in various cellular activities and discuss their potential role in neurodegenerative disorders.